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蔡佩君照片
Pei-Jiun Tsai

Ph.D. Associate Professor

Office: A132 # 67987

Lab: A129 # 65433,65434

pjtsai@vghtpe.gov.tw;pjtsai@nycu.edu.tw

Research

Welcome to our lab.
We are studying the efficacy of stem cell transplantation in diabetic disease. In the long term goal, we hope to develop a new treatment with stem cell or its derivatives to treat diabetes.

Faculty Profiles

蔡佩君副教授

Education

  • Ph.D. Institute of Clinical Medicine, National Yang-Ming University
  • Faculty of Medicine, National Yang-Ming University

Current Position

  • Associate Professor, Institute of Anatomy and Cell Biology, School of Medicine, National Yang Ming Chiao Tung University
  • Visiting Staff, Department of Critical Care Medicine, Taipei Veterans General Hospital

Research expertise

  • Wharton's jelly mesenchymal stem cell transplantation in diabetic disease model

Publication

  1. Hsiao CY, Chen TH, Chu TH, Ting YN, Tsai PJ*, Shyu JF*.. Calcitonin Induces Bone Formation by Increasing Expression of Wnt10b in Osteoclasts in Ovariectomy-Induced Osteoporotic Rats. Front Endocrinol (Lausanne). 2020; 11:613 (SCI).
  2. Chen TH, Kao SY, Chang HH, Shyu JF, Su CH, Tsai PJ*. Chronic Mesenteric Volvulus with Superior Mesenteric Venous Thrombosis: A Case Report. Clinics in Surgery 2020; (OI).
  3. Chen TH, Kao SY, Chang HH, Shyu JF, Su CH, Tsai PJ* A Case Report of a Pancreatic Sarcoma Combined with Autoimmune Pancreatitis. Clinics in Surgery 2020; : (OI).
  4. Chen TH, Su CH, Hsiao CY, Kao SY, Tsai PJ* Preemptive light sedation in intensive care unit may reduce pulmonary complications in geriatric receiving pancreaticoduodenectomy. Journal of the Chinese Medical Association 2020 (SCI).
  5. Hsiao CY, Chen TH, Huang BS, Chen PH, Su CH, Shyu JF, Tsai PJ* Comparison between the therapeutic effects of differentiated and undifferentiated Wharton's jelly mesenchymal stem cells in rats with streptozotocin-induced diabetes. World Journal of Stem Cells 2020; 12(2): (SCI).
  6. Tsai PJ, Yeh CC, Huang WJ, Min MY, Huang TH, Ko TL, Huang PY, Chen TH, Hsu Sanford PC *, Soong BW* and Fu YS*. Xenografting of human umbilical mesenchymal stem cells from Wharton's jelly ameliorates mouse spinocerebellar ataxia type 1. Translational Neurodegeneration 2019; 8(29): (SCI).
  7. Chu KA, Wang SY, Yeh CC, Fu TW, Fu YY, Ko TL, Chiu MM, Chen TH, Tsai PJ*, Fu YS*. Reversal of bleomycin-induced rat pulmonary fibrosis by a xenograft of human umbilical mesenchymal stem cells from Wharton's jelly. Theranostics 2019; 9(22): (SCI).
  8. Chen MS, Lin CY, Chiu YH, Chen CP, Tsai PJ, Wang HS. IL-1β-Induced Matrix Metalloprotease-1 Promotes Mesenchymal Stem Cell Migration via PAR1 and G-Protein-Coupled Signaling Pathway. Stem Cells International 2018(SCI).
  9. Chen MS, Lin CY, Chiu YH, Chen CP, Tsai PJ, Wang HS. IL-1β-Induced Matrix Metalloprotease-1 Promotes Mesenchymal Stem Cell Migration via PAR1 and G-Protein-Coupled Signaling Pathway. Stem Cells International 2018(SCI).
  10. Kao SY, Shyu JF, Wang HS, Hsiao CY, Su CH, Chen TH, Weng ZC, Tsai PJ*. Transplantation of Hepatocyte-like Cells Derived from Umbilical Cord Stromal Mesenchymal Stem Cells to Treat Acute Liver Failure Rat. Journal of Biomedical Sciences 2016; 4(1): (OI).
  11. Cheng CL, Chang HH, Chen TH, Tsai PJ, Huang YT, Huang PJ, Lin SY. Spectral and morphological classification of different chronic and acute Taiwanese gallstones via FTIR, SEM and ESEM-EDX microanalyses. DIGESTIVE AND LIVER DISEASE 2016; 48(5):519-27 (SCI).
  12. Lin CY, Zu CH, Yang CC, Tsai PJ, Shyu JF, Chen CP, Weng ZC, Chen TH, Wang HS. IL-1β-induced mesenchymal stem cell migration involves MLCK activation via PKC signaling. CELL TRANSPLANTATION 2015; 24(10):2011-28 (SCI).
  13. Tsai PJ, Wang HS, Lin GJ, Chou SC, Chu TH, Chuan WT, Lu YJ, Weng ZC, Su CH, Hsieh PS, Sytwu HK, Lin CH, Chen TH, Shyu JF. Undifferentiated Wharton's Jelly Mesenchymal Stem Cell Transplantation Induces Insulin-Producing Cell Differentiation and Suppression of T Cell-Mediated Autoimmunity in Non-Obese Diabetic Mice. CELL TRANSPLANTATION 2015; 24(8):1555-70 (SCI).
  14. Cheng CL, Chang HH, Chen TH, Tsai PJ, Ko SC, Chu YT, Huang PJ, Lin SY. Diagnosis and clinical characteristics of acute gallbladder sludge in a patient with acute myocarditis and acute cholecystitis, as compared with common chronic gallstones. Biomedical Spectroscopy and Imaging 2015; 4(1):67-9 (OI).
  15. Kao SY, Shyu JF, Wang HS, Lin CH, Su CH, Chen TH, Weng ZC, Tsai PJ. Comparisons of Differentiation Potential in Human Mesenchymal Stem Cells from Wharton's Jelly, Bone Marrow, and Pancreatic Tissues. Stem Cells International 2015; (SCI).
  16. Chang YC, Lee KH, Chen TH, Tsai PJ, Chen PY, Guo MC, Lin SA, Chen JY, Yang WC, Ng YY.. A case of intraperitoneal fracture of a double-cuff Tenckhoff catheter. PERITONEAL DIALYSIS INTERNATIONAL 2014; 34(1):132-4 (SCI).
  17. Kao SY, Lee TC, Weng ZC, Chen TH, Tsai PJ*. Treatment of obturator hernia in a patient undergoing peritoneal dialysis. PERITONEAL DIALYSIS INTERNATIONAL 2014; 34(7):803-5 (SCI).
  18. Tsai PJ, Wang HS, Lin CH, Weng ZC, Chen TH, Shyu JF. Intraportal injection of insulin-producing cells generated from human bone marrow mesenchymal stem cells decreases blood glucose level in diabetic rats. ENDOCRINE RESEARCH 2014; 39(1):26-33 (SCI).
  19. Tsai PJ, Wang SE, Shyr YM, Chen TH, Su CH, Wu CW. Diagnostic and therapeutic dilemmas in periampullary lesions. HEPATO-GASTROENTEROLOGY 2012; 117:1621-5 (SCI).
  20. Tsai PJ, Wang HS, Shyr YM, Weng ZC, Tai LC, Shyu JF, Chen TH. Transplantation of insulin-producing cells from umbilical cord mesenchymal stem cells for the treatment of streptozotocin-induced diabetic rats. JOURNAL OF BIOMEDICAL SCIENCE 2012; 19(1):47 (SCI).
  21. Tsai PJ, Liu KY, Wang SE, Shyr YM, Su CH, Chen TH. Solitary neurofibroma of the pancreas body not associated with type 1 neurofibromatosis. Journal of the Chinese Medical Association: JCMA 2012; 75(3):132-5 (SCI).
  22. Chien JS, Tsai PJ, Liu KY, Wang SE, Shyr YM, Su CH, Chen TH. Open Suture Repair and Open Onlay Technique for Incisional Hernia in Elderly Patients with Multiple Comorbidities. International Journal of Applied Science and Technology 2011; 1(3):34-40 (OI).
  23. Liu KY, Tsai PJ, King KL, Chen TH, Shyr YM, Su CH. Pseudoaneurysm of the iliac artery secondary to Aspergillus infection after kidney transplantation. Journal of the Chinese Medical Association: JCMA 2009; 72(12):654-6. (SCI).

Invited Presentations

  1. The therapeutic effect and mechanism of human umbilical cord Wharton's Jelly mesenchymal stem cells on bleomycin-induced pulmonary fibrosis rat,2020年 ISOMRM台灣國際再生醫學材料應用研討會,2020/12/13.
  2. 異種移植人類臍帶瓦頓式凝膠間質幹細胞逆轉Bleomycin誘導的大鼠肺纖維化,中國解剖學會/第二屆海峽兩岸暨港澳解剖學青年科學家論壇,2020/10/17.
  3. 以胃體分隔手術治療巨大消化性潰瘍穿孔的動物實驗與臨床應用,2018年中國—東盟衰老與疾病學術論壇暨廣西解剖學會2018年學術年會.
  4. 糖尿病的再生治療應用,2018年 中國解剖學會 學術年會.
  5. 擊退糖尿病的新希望-幹細胞治療,2017年BioPhalanx 生技研發論壇演講.
  6. 臍帶間質幹細胞的糖尿病治療機轉,2019年 中國解剖學會 學術年會.

Research Figures