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王先逸照片
Sabrina Wang

Ph.D. Associate Professor

Office: A120 # 67158

Lab: A113 , A115 # 65441

sabrina@nycu.edu.tw

Research

Welcome to our lab!
We use animal models to study the etiology and pathophysiological changes in major depression, which included changes in hypothalamic-pituitary-adrenal axis (HPA axis), orexin systems, and hippocampal neurogenesis. Recently we started to explore the microbiota-gut-brain axis and the potential of using psychobiotics to alleviate depression symptoms. Our long-term goal is to understand the etiology of major depression and develop prevention and new treatment strategies.

Research Area

Using animal models to study major depression
Explore the etiology and pathophysiological changes of depression, in order to develop new treatment strategies.

  1. The role of hippocampal neurogenesis in major depression
  2. The effects of prenatal lipopolysaccharide (LPS)- exposure on the stress response and affective behaviors in offspring
  3. Orexin system and major depression
  4. Animal studies of the potential of psychobiotics in the treatment of major depression

Faculty Profiles

王先逸副教授

Current Position

  • National Yang Ming  Chiao Tung University, Institute of Anatomy and Cell Biology, Associate Professor

EDUCATION

  • 1991-1997 Ph.D. Department of Physiology, University of Toronto, Toronto, Canada
  • 1985-1988 Ph.D. Department of Physiology, University of Toronto, Toronto, Canada
  • 1980-1984 B.Sc. Biology, Tunghai University, Taichung, Taiwan

Research expertise

  • Electrophysiology, Animal behaviors, Major depression research

PUBLICATIONS

  1. Chung-Wei Hsu and Sabrina Wang* (2021, Dec). Changes in the Orexin System in Rats Exhibiting Learned Helplessness Behaviors. Brain Sciences,11(12):1634. NSC 104-2320-B-010-012.
  2. Yi-Fan Ma, Yi-An Lin, Chin-Lin Huang, Chih-Chieh Hsu, Sabrina Wang*, Shih‐Rung Yeh*, Ying-Chieh Tsai* (2021, Aug). Lactiplantibacillus plantarum PS128 ‐ Alleviates Exaggerated Cortical Beta Oscillations and Motor Deficits in the 6‐Hydroxydopamine Rat Model of Parkinson’s Disease. Probiotics and Antimicrobial Proteins, doi: 10.1007/s12602-021-09828-x.
  3. Liao, J. F.; Cheng, Y. F.; You, S. T.; Kuo, W. C.; Huang, C. W.; Chiou, J. J.; Hsu, C. C.; Hsieh-Li, H. M.; Wang, S*.; Tsai, Y. C.*. Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson's disease. Brain Behav Immun. 2020; 90:26-46 (SCI).
  4. Liu, T.Y., Kuo, P.H., Lu, M.L., Huang, M.C., Chen, C.H., Wu, T.H., Wang, S., Mao, W.C., Chen, H.C.. Quantifying the level of difficulty to treat major depressive disorder with antidepressants: Treatment Resistance to Antidepressants Evaluation Scale. PLoS One 2020; 15(1):e0227614 (SCI).
  5. Chia-Li Wei, Sabrina Wang, Jui-Ting Yen, Yun-Fang Cheng, Chia-Li Liao, Chih-Chieh Hsu, Chien-Chen Wu d, and Ying-Chieh Tsai. Antidepressant-like activities of live and heat-killed Lactobacillus paracasei PS23 in chronic corticosterone-treated mice and possible mechanisms. Brain Research 2019; 1711:202-213 (SCI).
  6. Liao, JF; Cheng, YF; Li, SW; Lee, WT; Hsu, CC; Wu, CC; Jeng, OJ; Wang, S; Tsai, YC. Lactobacillus plantarum PS128 ameliorates 2,5-Dimethoxy-4-iodoamphetamine-induced tic-like behaviors via its influences on the microbiota-gut-brain-axis. BRAIN RESEARCH BULLETIN 2019; 153:59-73 (SCI).
  7. Cheng, L.H., Liu, Y.W., Wu, C.C., Wang, S., Tsai, Y.C.. Psychobiotics in mental health, neurodegenerative and neurodevelopmental disorders. JOURNAL OF FOOD AND DRUG ANALYSIS 2019; 27(3):632-648 (SCI).
  8. Yen-Chin Wang, Hai-Ti Lin, Mong-Liang Lu, Ming-Chyi Huang, Chun-Hsin Chen, Tzu-Hua Wu, Sabrina Wang, Wei-Chung Mao, Po-Hsiu Kuo, Hsi-Chung Chen. The Association between the Sedative Loads and Clinical Severity Indicators in the First-onset Major Depressive Disorder . Frontiers in Psychiatry 2019; : (SCI).
  9. Liao, T.-C., Lien, Y.-T., Wang, S., Huang, S.-L., Chan, C.-Y.. Comorbidity of Atopic Disorders with Autism Spectrum Disorder and Attention Deficit/Hyperactivity Disorder. JOURNAL OF PEDIATRICS 2016; 171:248-55. (SCI).
  10. Wu, W.-C., Luh, D.-L., Chiang, Y.-C., Huang, C.-C., Wang, S., Wu, C.-C., Hurng, B.-S., Chang, Y.-H., Yen, L.-L., Chang, H.-Y.. Reciprocal relationship between unhealthy eating behaviours and depressive symptoms from childhood to adolescence: 10-year follow-up of the Child and Adolescent Behaviors in Long-Term Evolution study. Public Health Nutrition 2016; 19(9):1654-65 (SCI).
  11. Liu, C.-P., Wu, T.-H., Lin, Y.-L.., Liu, C.-Y., Wang, S., Lin, S.-Y.. Tailoring Enzyme-Like Activities of Gold Nanoclusters by Polymeric Tertiary Amines for Protecting Neurons Against Oxidative Stress. Small 2016; 12(30):4127-35 (SCI).
  12. Liu, W.-H., Chuang, H.-L., Huang, Y.-T., Wu, C-C., Chou, G.-T., Wang, S., and Tsai, Y.-C.. Alteration of behavior and monoamine levels attributable to Lactobacillus plantarum PS128 in germ –free mice. BEHAVIOURAL BRAIN RESEARCH 2016; 298:202-209 (SCI).
  13. Liu, Y.-W., Liu, W.-H., Wu, C.-C., Juan, Y.-C., Wu, Y.-C., Tsai, H.-P., Wang, S., Tsai, Y.-C.. Psychotropic effects of Lactobacillus Plantarum PS128 in early life-stressed and naïve adult mice. BRAIN RESEARCH 2016; 1631:1-12 (SCI).
  14. Mosa, AJ; Wang, S; Tan, YF; Wojtowicz, JM. Organotypic Slice Cultures for Studies of Postnatal Neurogenesis. Jove-Journal of Visualized Experiments 2015; 97(dio:10.3791/52353): (OI).
  15. Fang, S.-Y., Wang, S., Huang, N., Yeh, H.-H., Chen, C.-Y.. Prenatal infection and autism spectrum disorders in childhood: A population-based case-control study in Taiwan. PAEDIATRIC AND PERINATAL EPIDEMIOLOGY 2015; 29(4):307-16 (SCI).
  16. Lin, Y.-L. and Wang, S.. Prenatal LPS exposure increases depression-like behaviors and reduces hippocampal neurogenesis in adult rats. BEHAVIOURAL BRAIN RESEARCH 2014; 259:24-34 (SCI).
  17. Lin, Y.-L., Lin, S.-Y., Wang, S.. Prenatal lipopolysaccharide exposure increases anxiety-like behaviors and enhances stress-induced corticosterone responses in adult rats. BRAIN BEHAVIOR AND IMMUNITY 2012; 26(3):459-468 (SCI).
  18. Wu, H.H. and Wang, S.. Strain differences in the chronic mild stress animal model of depression. BEHAVIOURAL BRAIN RESEARCH 2010; 213(1):94-102 (SCI).
  19. Ho, Y.-C. and Wang, S.. Adult neurogenesis is reduced in the dorsal hippocampus of rats displaying learned helplessness behavior. Neurosciences 2010; 171(1):153-61 (SCI).
  20. Wang, S., Yan J.Y., Lo, Y.K., Carvey, P.M. and Ling, Z.. Dopaminergic and serotoninergic deficiencies in young adult rats prenatally exposed to the bacterial lipopolysaccharide. BRAIN RESEARCH 2009; 1265:196-204 (SCI).
  21. Winocur, G., Wojtowicz, J.M., Sekeres, M., Snyder, J.S., Wang, S.. Inhibition of neurogenesis interferes with hippocampus-dependent memory function. Hippocampus 2006; 16(3):296-304 (SCI).
  22. Wang, S., Kee, N., Preston, E. and Wojtowicz, J.M.. Electrophysiological correlates of neural plasticity compensating for ischemia-induced damage in the hippocampus. EXPERIMENTAL BRAIN RESEARCH 2005; 165(2):250-60. (SCI).


Invited Presentations

  1. 2017/3/26 Animal studies of the potential of psychobiotics in the treatment of major depression. Invited by The Association of Anatomists of the Republic of China, The 31th Joint Annual Conference of Biomedical Science
  2. 2013/3/23 The Potential Roles of Adult Neurogenesis and Maternal Infection in the Etiology of Major Depression. Invited by The Association of Anatomists of the Republic of China, The 28th Joint Annual Conference of Biomedical Science