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鄭瓊娟照片
Chung Jiuan Jeng

Ph.D. Professor

Office: A128 # 7072

Lab: A117,A119 # 5439,5440

cjjeng@ym.edu.tw

Research

Welcome to our lab! We currently have two research directions: (1) channelopathy, (2) signaling mechanisms underlying the neuroinflammation. By understanding the pathophysiological mechanisms of ion channel diseases and the impact of neuroinflammation, we may develop ways to prevent and treat these diseases in the future.

Research Area

  1. Molecular assembly and gene regulation of ion channels.
  2. Biosynthesis and trafficking of ion channels.
  3. Pathophysiology of ion channel diseases.
  4. Neuroinflammation.


Faculty Porfiles

鄭瓊娟教授(兼所長科主任)

Current Position

  • Professor/Department of Anatomy and Cell Biology

EDUCATION

  • Anatomy and Cell Biology, University of California, Los Angeles, USA
  • Anatomy and Cell Biology, National Taiwan University, Taiwan
  • Physical Therapy, National Taiwan University, Taiwan

APPOINTMENTS

  • Assistant Professor, School of Medicine, Fu-Jen University, Taiwan
  • Research scientist, AbGenomics Corp, Taipei, Taiwan
  • Postdoctoral fellowship, California Institute of Technology, USA
  • Postdoctoral fellowship, University of California, Los Angeles, USA
  • Teaching assistant, Department of Anatomy, National Taiwan University, Taiwan

Honors and Awards

  • 2018 Excellent Teaching Award, National Yang-Ming University
  • 2011 Excellent Teaching Glazed Trophy, College of Medicine,, National Yang-Ming University
  • 2008 Excellent Teaching Award, National Yang-Ming University

Research expertise

Ion channel, Neuroscience

PUBLICATIONS

  1. C.-T. Hsiao, S.-J. Fu, Y.-T. Liu, Y.-H. Lu, C.-Y. Zhong, C.-Y. Tang, B.-W. Soong*, C.-J. Jeng* (2019) Novel SCA19/22-associated KCND3 mutations disrupt human KV4.3 protein biosynthesis and channel gating. Human Mutation 40:2088–2107.
  2. Y.-J. Peng, Y.-C. Lee, S.-J. Fu, Y.-C. Chien, Y.-F. Liao, T.-Y. Chen, C.-J. Jeng*, C.-Y. Tang* (2018) FKBP8 enhances protein stability of CLC-1 chloride channel at the plasma membrane. International Journal of Molecular Sciences. 9: 3783, doi:10.3390/ijms19123783
  3. P.-H. Hsu, Y.-T. Ma, Y.-C. Fang, J.-J. Huang, Y.-L. Gan, P.-T. Chang, G.-M. Jow, C.-Y. Tang*, and C.-J. Jeng* (2017) Cullin 7 mediates proteasomal and lysosomal degradations of rat Eag1 potassium channels. Scientific Reports 7:40825, DOI: 10.1038.
  4. S.-J. Fu, C.-J. Jeng, C.-H. Ma, Y.-J. Peng, C.-M. Lee, Y.-C. Fang, Y.-C. Lee, S.-C. Tang, M.-C. Hu, and C.-Y. Tang* (2017) Ubiquitin ligase RNF138 promotes episodic ataxia type 2-associated aberrant degradation of human CaV2.1 (P/Q-type) calcium channels. Journal of Neuroscience 37(9):2485–2503.
  5. P.-H. Hsu, Y.-C. Chiu, T.-F. Lin, and C.-J. Jeng* (2016) Ca2+-binding protein centrin 4 is a novel binding partner of rat Eag1 K+ channels. FEBS Open Bio doi:10.1002/2211-5463.12045.
  6. Y.-C. Teng, C.-J. Jeng, H.-J. Huang, A. M.-Y. Lin (2015) Role of autophagy in arsenite-induced neurotoxicity: The involvement of alpha-synuclein. Toxicology Letters 233: 239-245.
  7. T.-F. Lin, G.-M Jow, H.-Y. Fang, S.-J. Fu, H.-H. Wu, M.-M. Chiu, and C.-J. Jeng* (2014) The eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels. PLoS ONE 9(10): e110423.
  8. T.-F. Lin, I-W. Lin, S.-C. Chen, H.-H. Wu, C.-S. Yang, H.-Y Fang, M.-M. Chiu, and C.-J. Jeng* (2014) The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains. Journal of Biological Chemistry 289(33):22815-22834.
  9. C.-C. Chuang, G.-M. Jow, H.-M. Lin, Y.-H. Weng, J.-H. Hu, Y.-J. Peng, Y.-C. Chiu, M.-M. Chiu, C.-J. Jeng* (2014) The punctate localization of rat Eag1 K+ channels. BMC Neuroscience 15:23.
  10. C.-K. Liao, C.-J. Jeng, H.-S. Wang, S.-H. Wang, J.C. Wu (2013) Lipopolysaccharide induces degradation of connexin43 in rat astrocytes via the ubiquitin-proteasome proteolytic pathway. PLoS ONE 8(11): e79350.
  11. P.-H. Hsu, S.-C. Miawa, C.-C. Chuang, P.-Y. Chang, S.-J. Fu, G.-M. Jow, M.-M. Chiu, C.-J. Jeng* (2012) 14-3-3theta is a Binding Partner of Rat Eag1 potassium Channels. PLoS ONE 7(7): e41203.
  12. S.-H. Yang, C.-C. Liao, Y. Chen, J.-P. Syu, C.-J. Jeng*, and S.-M. Wang (2012) Daidzein induces neuritogenesis in DRG neuronal cultures. Journal of Biomedical Science 19:80.
  13. I.-H. Chen, J.-H. Hu, G.-M. Jow, C.-C. Chuang, T.-T. Lee, D.-C. Liu, and C.-J. Jeng* (2011) The distal end of carboxyl-terminus is not essential for the assembly of rat Eag1 potassium channels. Journal of Biological Chemistry 286(31) 27183–27196.
  14. Y.-P. Lai, C.-J. Jeng, and S.-C. Chen (2011) The roles of CD4+ T cells in tumor immunity. ISRN Immunology Volume 2011, Article ID 497397, 6 pages.
  15. S.-H. Yang; C.-J. Jeng, C-H Chen, Y. Chen, Y.-C. Chen, and S.-M. Wang (2011) Schisandrin enhances dendrite outgrowth and synaptogenesis in primary cultured hippocampal neurons. Journal of the Science of Food and Agriculture 91(4): 694–702.
  16. J.-Y. Deng, S.-J. Chen, G.-M. Jow, C.-W. Hsueh, and C.-J. Jeng* (2009) Dehydroeburicoic acid induces calcium- and calpain-dependent necrosis in human U87MG glioblastomas. Chemical Research Toxicology 22, 1817–1826.
  17. G.-M. Jow and C.-J. Jeng* (2008) Differential localization of rat Eag1 and Eag2 potassium channels in the retina. Neuroscience Letters 24; 431(1):12-6.
  18. Y.-C. Lien, H.-N. Kung, K.-S. Lu*, C.-J. Jeng*, Y.-P. Chau (2008) Involvement of endoplasmic reticulum stress and activation of MAP kinases in beta-lapachone-induced human prostate cancer cell apoptosis. Histology and Histopathology. 23(11):1299-308.
  19. P. Wang, C.-J. Jeng, C.-L., Chien S.-M. Wang (2008) Signaling mechanisms of daidzein-induced axonal outgrowth in hippocampal neurons. Biochemical and Biophysical Research Communications 338:1417-1425.
  20. C.-J. Jeng, M.-C. Sun, Y.-W. Chen, and C.-Y. Tang (2008) Dominant-negative effects of episodic ataxia type 2 mutations involve disruption of membrane trafficking of human P/Q-type Ca2+ channels. Journal of Cellular Physiology 214(2):422-33.
  21. S.-H. Yang, Y.-J. Chen, P.-Y. Tung, W.-L. Lai, Y Chen, C.-J. Jeng*, and S.-M. Wang (2008) Anti-Thy-1 antibody-induced neurite outgrowth in cultured dorsal root ganglionic neurons is mediated by the c-Src-MEK signaling pathway. Journal of Cellular Biochemistry 103(1):67-77.
  22. C.-H. Chen, Y.-J. Chen, C.-J. Jeng, S.-H. Yang, and S.-M. Wang (2007) Role of PKA in Thy-1 antibody-induced neurite outgrowth in dorsal root ganglionic neurons. Journal of Cellular Biochemistry 101(3):566-575.
  23. C.-J. Jeng, Y.-T. Chen, Y.-W. Chen, and C.-Y. Tang (2006) Dominant-negative effects of human P/Q-type Ca2+ channel mutations associated with episodic ataxia type 2. Am. J. Physiol. Cell Physiol 290: C1209–C1220.
  24. J.-H. Yeh, C.-J. Jeng, Y.-W. Chen, H.-M. Lin, Y.-S. Wu, and C.-Y. Tang (2005) Selective enhancement of tonic inhibition by increasing ambient GABA is insufficient to suppress excitotoxicity in hippocampal neurons. Biochem. Biophys. Res. Commun. 338, 1417-1425
  25. C.-Y. Tang, Y.-W. Chen, G.-M. Jow, C.-J. Chou, and C.-J. Jeng* (2005) Beauvericin activates Ca2+-activated Cl- currents and induces cell deaths in Xenopus oocytes via influx of extracellular Ca2+. Chem Res Toxicol 18: 825-833.
  26. L.-J. Yang, C.-J. Jeng, H.-N. Kung, C.-C. Chang, A.-G. Wang, G.-Y. Chau, M.-J. Don, Y.-P. Chau (2005) Tanshinone IIA isolated from Salvia miltiorrhiza elicits the cell death of human endothelial cells. J. Biomed. Sci. 12: 347-361.
  27. C.-J. Jeng, C.-C. Chang, and C.-Y. Tang (2005) Differential localization of rat Eag1 and Eag2 K+ channels in hippocampal neuron. Neuroreport 16:229-233.
  28. C.-H. Chen, S.-M. Wang, S.-H. Yang, and C.-J. Jeng* (2005) Role of Thy-1 in in vivo and in vitro neural development and regeneration of dorsal root ganglionic Neurons. J. Cell Biochem 94(4):684-94.
  29. S.-C. Chen, C.-C. Huang, C.-C. Chien, C.-J. Jeng, H.-T. Su, E. Chiang, M.-R. Liu, H. Wu, C.-N. Chang, and R.-H. Lin* (2004) Cross-linking of P-selectin glycoprotein ligand-1 induces death of activated T cells. Blood 104(10): 3233-3242.
  30. R.S. Walikonis, A. Oguni, E.M. Khorosheva, C.-J. Jeng, F.J. Asuncion, and M.B. Kennedy (2001) Densin-180 forms a ternary complex with the a-subunit of CaMKII and a–actinin. J. Neurosci. 21(2): 423-422.
  31. C.-J. Jeng, S. McCarroll, T.F. Martin, E. Floor, J. Adams, D. Krantz, S. Butz, R Edwards, and E.S. Schweitzer (1998) Thy-1 is a component common to multiple populations of synaptic vesicles. J. Cell Biol. 140, 685-698.

Invited Presentations

  1. Proteostatic Mechanism of Eag1 Potassium Channel, 29th Ion Channel Meeting, CANAUX IONIQUES, Sète, France, 9/11/2018.
  2. Regulation of Ether-à-go-go Potassium Channel Expression by RING E3 Ubiquitin Ligases, The 33th Joint Annual Conference of Biomedical Science, Taipei, Taiwan, 3/24/2018.
  3. Protein Interaction Mechanisms of EAG Potassium Channels, Internal Symposium in Osaka University, Osaka, Japan, 8/3/2017.
  4. Protein Targeting and Molecular Assembly of Ether-à-go-go Potassium Channels, The 31th Joint Annual Conference of Biomedical Science, Taipei, Taiwan, 3/26/2016.