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王懷詩照片
Hwai-Shi Wang

Ph.D. Professor

Office: A116 # 7035

Lab: A121,A123 # 5437,5438

hswang@ym.edu.tw

Research

The main research focus of this laboratory include: 1. Mechanisms in cancer cell metastasis. 2. Mechanisms involved in human umbilical cord migration in cell therapy. 3. The effects of different biomaterials on stem cell differentiation.

Faculty Porfiles

王懷詩教授

EDUCATION

  • Georgetown University , USA 1990

Current Position

  • Yang Ming University, Institute of Anatomy and Cell Biology,Professor

Research expertise

  1. The role of CD44 in cancer metastasis.
  2. Effects of biomaterials in mesenchymal stem cell differentiation.
  3. Effect of Mesenchymal Stem Cells in rheumatoid arthritis.

PUBLICATIONS

( A)期刊發表
  1. Yu-Chien Guo, Yun-Hsuan Chiu, Chie-Pein Chen and Hwai-Shi Wang. Interleukin-1β induces CXCR3-mediated chemotaxis to promote umbilical cord mesenchymal stem cell transendothelial migration. Stem Cell Research and Therapy 2018; 9:281-295 (SCI).
  2. Chen, M.-S., Lin, C.-Y. Lin, Chiu, Y.-H, Chen, C.-P., Tsai, P.-J. and Wang, H.-S.. IL-1s Induced Matrix Metalloprotease-1 Promotes Mesenchymal Stem Cell Migration via PAR1 and G-protein Coupled Signaling Pathway. Stem Cells International 2018; article ID 3524759 (SCI).
  3. Yun-Li Lin, Chie-Pein Chen, Chun-Min Lo, Hwai-Shi Wang. Stiffness-controlled three-dimensional collagen scaffolds for differentiation of human Wharton's jelly mesenchymal stem cells into cardiac progenitor cells. Journal of Biomedical Materials Research Part A 2016; 104(9):2234-2242 (SCI).
  4. Chi-Ting Chiu, Chih-Kai Liao, Chien-Chang Shen, Tswen-Kei Tang, Guey-Mei Jow, Hwai-Shi Wang, Jiahn-Chun Wu. HYS-32-Induced Microtubule Catastrophes in Rat Astrocytes Involves the PI3K-GSK3beta Signaling Pathway. PLoS One 2015; 10(5):e0126217 (SCI).
  5. Shih-Yi Kao, Jia-Fwu Shyu, Hwai-Shi Wang, Chi-Hung Lin, Cheng-Hsi Su, Tien-Hua Chen, Zen-Chung Weng and Pei-Jiun Tsai. Comparisons of Differentiation Potential in Human Mesenchymal Stem Cells from Wharton’s Jelly, Bone Marrow, and Pancreatic Tissues. Stem Cells International 2015; 29:306158 (SCI).
  6. 6. Shih-Yi Kao, Jia-Fwu Shyu, Hwai-Shi Wang, Chen-Yuan Hsiao, Cheng-Hsi Su, Tien-Hua Chen, Zen-Chung Weng, Pei-Jiun Tsai.. Transplantation of Hepatocyte-like Cells Derived from Umbilical Cord Stromal Mesenchymal Stem Cells to Treat Acute Liver Failure Rat. Journal of Biomedical Sciences 2015; 2015(7):1-9 (SCI).
  7. Chen-Yuan Hsiao, Pei-Jiun Tsai, Pei-Chun Chu, Shin-I Liu, Chia-Hsin Pan, Chie-Pein Chen, Cheng-Hsi Su, Zen-Chung, Weng, Tien-Hua Chen, Jia-Fwu Shyu, Hsiao-Huang Chang, Hwai-Shi Wang. Transplantation of Wharton's Jelly Mesenchymal Cells to Improve Cardiac Function in Myocardial Infarction Rats. Journal of Biomedical Sciences 2015; 5(1):1-12 (SCI).
  8. Pei-Jiun Tsai; Hwai-Shi Wang; Gu-Jiun Lin; Shu-Cheng Chou; Tzu-Hui Chu; Wen-Ting Chuan; Ying-Jui Lu; Zen-Chung Weng; Cheng-Hsi Su; Po-Shiuan Hsieh; Huey-Kang Sytwu; Chi-Hung Lin; Tien-Hua Chen; Jia-Fwu Shyu. Undifferentiated Wharton’s jelly mesenchymal stem cell transplantation induces insulin-producing cell differentiation and suppression of T cell-mediated autoimmunity in non-obese diabetic mice. Cell Transplantation 2015; 24(8):1555-1570 (SCI).
  9. Cheng-Yu Lin, Chia-Hua Zu, Chih-Chang Yang, Pei-Jiun Tsai, Jia-Fwu Shyu, Chie-Pein Chen, Zen-Chung Weng, Tien-Hua Chen, Hwai-Shi Wang. IL-1β-induced mesenchymal stem cell migration involves MLCK activation via PKC signaling. Cell Transplantation 2015; 24:2011-2028 (SCI).
  10. Chun-Ming Shih, Chun-Yao Huang, Li-Rung Liao, Chiao-Po Hsu, Nai-Wen Tsao, Hwai-Shi Wang, Wei-Yuan Chen, Yea-Yang Su, Shing-Jong Lin, Chun-Che Shih, Feng-Yen Lin. Nickel ions from a corroded cardiovascular stent induce monocytic cell apoptosis: Proposed impact on vascular remodeling and mechanism. Journal of Formosan Medical Association 2014; online: (SCI).
  11. Pei-Jiun Tsai, Hwai-Shi Wang, Chi-Hung Lin, Zen-Chung Weng, Tien-Hua Chen and Jia-Fwu Shyu. Intraportal injection of insulin-producing cells generated from human bone marrow mesenchymal stem cells decreases blood glucose level in diabetic rats. Endocrine Research 2014; 39(1):26-33 (SCI).
  12. Yu-Fang Huang, Chih-Kai Liao, Jau-Chen Lin, Guey-Mei Jow, Hwai-Shi Wang, Jiahn-Chun Wu. Antofine-induced connexin43 gap junction disassembly in rat astrocytes involves protein kinase Cb. NeuroToxicology 2013; 35:169-179 (SCI).
  13. Chih-Kai Liao, Chung-Jiuan Jeng, Hwai-Shi Wang, Shu-Huei Wang, Jiahn-Chun Wu. Lipopolysaccharide induces degradation of connexin43 in rat astrocytes via the ubiquitin-proteasome proteolytic pathway. Plos One 2013; 8(11):e79350 (SCI).
  14. Chih-Chang Yang, Cheng-Yu Lin, Hwai-Shi Wang, Shaw-Ruey Lyu. Matrix metalloproteases and tissue inhibitors of metalloproteinases in medial plica and pannus-like tissue contribute to knee osteoarthritis progression. Plos One 2013; 8(11):e79662 (SCI).
  15. Pei-Jiun Tsai, Hwai-Shi Wang, Yi-Ming Shyr, Zen-Chung Weng, Ling-Chen Tai, Jia-Fwu Shyu, Tien-Hua Chen. Transplantation of insulin-producing cells from umbilical cord mesenchymal stem cells for the treatment of streptozotocin-induced diabetic rats. Journal of Biomedical Science 2012; 19:47-55 (SCI).
  16. Chang-I Kung, Cheng-Yi Chen, Chih-Chang Yang, Cheng-Yu Lin, Tien-Hua Chen, Hwai-Shi Wang. Enhanced membrane-type 1 matrix metalloproteinase expression by hyaluronan oligosaccharides in breast cancer cells facilitates CD44 cleavage and tumor cell migration. Oncology Reports 2012; 28:1808-1814 (SCI).
  17. Hwai-Shi Wang, Jia-Fwu Shyu, Wen-Sheng Shen, Hsin-Chi Hsu, Torng-Chien Chi, Chie-Pein Chen, Seng-Wong Huang, Yi-Ming Shyr, Kam-Tsun Tang, Tien-Hua Chen. Transplantation of insulin producing cells derived from umbilical cord stromal mesenchymal stem cells to treat NOD mice. Cell Transplantation 2011; 20:455-466 (SCI).
  18. Jia-Fwu Shyu, Hwai-Shi Wang, Yi-Ming Shyr, Shin-E Wang, Chia-Hsiang Chen, Joo-Shin Tan, Meng-Feng Lin, Tien-Hua Chen. Alleviation of hyperglycemia in diabetic rats by intraportal injection of insulin-producing cells generated from surgically resected human pancreatic tissue. Journal of Endocrinology 2011; 208:233-244 (SCI).
  19. Hwai-Shi Wang, Pei-Yin Kuo, Chih-Chang Yang, Shaw-Ruey Lyu. Matrix metalloprotease-3 expression in the medial plica and pannus-like tissue in knees from patients with medial compartment osteoarthritis. Histopathology 2011; 58:593-600 (SCI).
  20. Chih-Kai Liao, Seu-Mei Wang, Yuh-Lien Chen, Hwai-Shi Wang, Jiahn-Chun Wu. Lipopolysaccharide-induced inhibition of connexin43 gap junction communication in astrocytes is mediated by downregulation of caveolin-3. International Journal of Biochemistry & Cell Biology 2010; 42:762-770 (SCI).
  21. Yi-Chih Kuo, Cheng-Hsi Su, Chin-Yi Liu, Tien-Hua Chen, Chie-Pein Chen, and Hwai-Shi Wang. Transforming growth factor-beta induces CD44 cleavage that promotes migration of MDA-MB-435s cells through the up-regulation of membrane type 1-matrix metalloproteinase. International Journal of Cancer 2009; 124:2568-2576 (SCI).
  22. Shu-Tine Peng, Cheng-His Su, Chun-Chi Kuo, Chen-Fu Shaw, Hwai-Shi Wang. CD44 crosslinking-mediated matrix metalloproteinase-9 relocation in breast tumor cells leads to enhanved metastasis. International Journal of Oncology 2007; 31:1119-1126 (SCI).
  23. Hwai-Shi Wang, Wen-Hsiu Tung, Kam-Tsun Tang, Yi-Kuei Wong, Ging-Jye Huang, Jiahn-Chun Wu, Yi-Jhih Guo, Chin-Chang Chen. TGF-beta induced hyaluronan synthesis in orbital fibroblasts involves protein kinase C betaII activation in vitro. Journal of Cellular Biochemistry 2005; 95:256-267 (SCI).
  24. Hwai-Shi Wang, Ying Hung, Cheng-Hsi Su, Shu-Ting Peng, Yi-Jhih Guo, Ching-Yi Liu, Mei-Chun Lai, Jia-Wei Hsu. CD44 cross-linking induces integrin-mediated adhesion and transendothelial migration in breast cancer cell line by up-regulation of LFA-1 (αLβ2) and VLA-4 (α4β1). Experimental Cell Research 2005; 1:116-126 (SCI).
  25. Hwai-Shi Wang, Shih-Chieh Hung, Shu-Tine Peng, Chun-Chieh Huang, Yi-Jhih Guo, Hung-Mu Wei, Yu-Show Fu, Mei-Chun Lai, Chin-Chang Chen. Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord. Stem Cells 2004; 22:1330-1337 (SCI).
  26. Negash, S., Wang, H.-S., Gao C, D Ledee, D., Zelenka, P.. Cdk5 regulates cell-matrix and cell-cell adhesion in lens epithelial cells. Journal of Cell Science 2002; 115:2109-2117 (SCI).
  27. Gao C., Negash, S., Guo, H.T., Dolena Ledee, D., Wang, H.-S., Zelenka, P.. CDK5 regulates cell adhesion and migration in corneal epithelial cells. Molecular Cancer Research 2002; 1:12-24 (SCI).
  28. Wong, Y.-K., Tang, K.-T., Wu, J.-C., Hwang, J.-J., Wang, H.-S. Stimulation of hyaluronan synthesis by interkeukin-1 involves activation of protein kinase C beta II in fibroblasts from patients with Graves’ophthalmopathy. Journal of Cellular Biochemistry 2001; 82:58-67 (SCI).
  29. Gao, C., Negash, S., Wang, H.-S., Ledee, D., Guo, H., Russel, P., Zelenka, P.. CDK5 mediates changes in morphology and promotes apoptosis of astrocytoma cells in response to heat shock. Journal of Cell Science 2001; 114:1145-1153 (SCI).
  30. Reddy, L., Wang, H.-S., Keese, C.R., Giaever, I., and Smith, T.J.. Assessment of rapid morphological changes associated with elevated cAMP levels in human orbital fibroblasts. Experimental Cell Research 1998; 245:360-367 (SCI).
  31. Cao, H.J., Wang, H.-S., Zhang, Y., Lin, H.-Y., Phipps, R.P., and Smith, T.J.. Activation of human orbital fibroblasts through CD40 engagement results in a dramatic induction of hyaluronan synthesis and prostaglandin endoperoxide H synthase-2 expression: Insights into potential pathogenic mechanisms of thyroid-associated ophthalmopathy. Journal of Biological Chemistry 1998; 273:29615-29625 (SCI).
  32. Smith, T.J., Sempowski, G.D., Berneson, C.S., Cao, H.J., Wang, H.-S., and Phipps, R.P.. Human thyroid fibroblasts exhibit a distinctive phenotype in culture: characteristic ganglioside profile and functional CD40 expression. Endocrinology 1997; 138:5576-5588 (SCI).
  33. Smith, T.J., Piscatelli, J.J., Andersen, V., Wang, H.S., Lance, P.. n-Butyrate induces plasminogen activator inhibitor type 1 messenger RNA in cultured Hep G2 cells 23:866-871. Hepatology 1996; 23:866-871 (SCI).
  34. Wang, H.-S., Winn, V.D., Rezanka, L.J., Cao, H.J., Frobert, Y., Sciaky, D.,Evan, C.H., Young, D.A., and Smith T.J.. Leukoregulin induction of cyclooxygenase-2 expression in human orbital fibroblasts. Journal of Biological Chemistry 1996; 271:22718-22718 (SCI).
  35. Qiao, R.-L., Wang, H.-S., Yan, W., Odekon, L.E., Del Vecchio, P.J., Smith, T.J., and Malik, A.B.. Hyaluronan synthesis in extracellular matrix is a determinant of endothelial barrier. American Journal of Physiology-Cell Physiology 1995; 269:C103-C109 (SCI).
  36. Smith, T.J., Wang, H.-S., and Evans, C.H.. Leukoregulin is a potent inducer of hyaluronan synthesis in cultured orbital fibroblasts. American Journal of Physiology-Cell Physiology 1995; 268:C382-C388 (SCI).
  37. Wang, H.-S., Keese, C.R., Giaever, I. And Smith, T.J.. Prostaglandin E2 alters human orbital fibroblast through a mechanism involving the generation of cyclic adenosine monophosphate. Journal of Clinical Endocrinology and Metabolism 1995; 80:3553-3560 (SCI).
  38. Smith, T.J., Sempowski, G.D., Wang, H.-S., Del Vecchio, P.J., Lippe, S., and Phipps, R.P.. Evidence for cellular heterogeneity in primary cultures of human orbital fibroblasts. Journal of Clinical Endocrinology and Metabolism 1995; 80:2620-2625 (SCI).
  39. Smith, T.J., Wang, H.-S., Hong, M.G., Henrikson, R.C., Keese, C.R. and Giaever, I.. Prostaglandin E2 elicits a morphological change in cultured orbital fibroblasts from patients with Graves’ophthalmopathy. Proceedings of the National Academy of Sciences of the United States of America 1994; 91:5094-5098 (SCI).
  40. Wang, H.-S., Underhill, C.B.. Hyaluronan can be non-enzymatically link to protein through an alkaline sensitive bond. Connective Tissue Research 1992; 28:29-48 (SCI).
( B)專書發表
出版年度 作者 專書/專章名稱 出版社/學術專書
2012 S.R. Lyu, D.S. Liu, C.E. Tseng, H.S. Wang and L.K. Chau (ISBN 978-953-51-0168-0)Osteoarthritis-Diagnosis, Treatment and Surgery, edited by Qian Chen Intechweb.org