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People

傅毓秀照片
Yu-Show Fu

Ph.D. Professor

Office: A126 # 7254

Lab: B122,B124 # 5415,5416

ysfu@ym.edu.tw

Research

Welcome to Laboratory of Human Umbilical Mesenchymal Stem Cells and Regenerative Medicine Research.
In our laboratory, we have been exploring the therapeutic potential of mesenchymal stem cells (MSCs) in Wharton’s jelly from the umbilical cord for various diseases. We want to discover the potentials and values of human umbilical mesenchymal stem cells on the regenerative medicine.


Research Area

Human mesenchymal cells from Wharton’s jelly of the umbilical cord are obtained from medical waste after delivery and therefore carry little ethical concerns. We previously have shown that HUMSCs are viable after being engrafted into the striatum, hippocampi, cerebral cortex and spinal cord of rats without the need for immunological suppression. In addition to the central nervous system disorders, HUMSCs transplants also exhibit promising therapeutic potentials in rats with liver fibrosis, peritoneal fibrosis, pulmonary fibrosis and type 1 diabetes. These results indicate that HUMSCs possess the ability for long-term survival and remain functional within various host organs of the rat, suggesting that HUMSCs are a good stem cell source for xeno-transplantation.
We currently are aimed to further apply the HUMSCs transplantation in regeneration medicine.

Faculty Porfiles

傅毓秀教授

NEWS

  1. 東森電視台:
  2. FORMOSA NEWS (2019/08/28)
    - Stem cells therapy for lung scarring (video)
    教授
  3. 自由時報的頭版,20190826
    教授
  4. 台灣電視台:
    全球首見可逆轉式修復菜瓜布肺有救了 (影音)
  5. 八大電視台:
    菜瓜布肺有救了!幹細胞治療逆轉 (影音)
  6. 民視新聞台
    台灣醫療獨步 菜瓜布肺有救 (影音)
  7. 公視新聞台
    臍帶間質幹細胞治肺纖維化 竟修復 (影音)
  8. 中華電視台
    "菜瓜布肺"有解 幹細胞治療逆轉修復 (影音)
  9. 中央社報導
    幹細胞逆轉菜瓜布肺 台灣團隊領先全球 (網路連結)
  10. 自由時報電子報
    幹細胞治療 逆轉修復 菜瓜布肺有救了 (網路連結)
  11. 中央廣播電台
    台醫學研究領先全球 幹細胞逆轉菜瓜布肺 (網路連結)
  12. 青年日報
    幹細胞逆轉菜瓜布肺 臺灣團隊領先全球 (網路連結)
  13. 匯流新聞網
    死亡率勝癌症的菜瓜布肺 能軟回來了!台灣研究:幹細胞治療能修復 (網路連結)
  14. 中國廣播公司
    菜瓜布肺有救!台灣團隊用幹細胞逆轉 領先全球 (網路連結)
  15. Link富聯網
    父親菜瓜布肺過世 陽明教授研發幹細胞療法 (網路連結)

EDUCATION

  • National Taiwan University, ROC 1996

Current Position

  • Professor

APPOINTMENTS

  • 國立陽明大學、解剖學及細胞生物學科、副教授
  • 國立陽明大學、解剖學及細胞生物學科、講師

Honors and Awards

  • 99-106學年度醫學系網路教學評鑑之優良教師

Research expertise

  • Stem cell research on regenerative medicine

PUBLICATIONS

  1. Chu KA, Wang SY, Yeh CC, Fu TW, Fu YY, Ko TL, Chiu MM, Tsai PJ*, Fu YS*. Reversal of bleomycin-induced rat pulmonary fibrosis by a xenograft of human umbilical mesenchymal stem cells from Wharton’s jelly. 2019 Theranostics. 9(22): 6646- 6664. (通訊作者)
  2. Yeh CC, Huang WJ, Min MY, Huang TH, Ko TL, Huang PY, Wang PH, Hsu Sanford P.C., Soong BW, Fu YS*. Xenografting of Human Umbilical Mesenchymal Stem Cells from Wharton’s Jelly Ameliorates Mouse Spinocerebellar Ataxia type 1. 2019 Translational Neurodegeneration. 8(29): 1-13. (通訊作者)
  3. Hsu SPC, Wang DY, Min MY, Fu YS*. Long-Term Challenge of Methylphenidate Changes the Neuronal Population and Membrane Property of Dopaminergic Neuron in Rats. 2019 Neurochemistry International. 122: 187- 195. (通訊作者)
  4. Fu YS, Lu CH, Chu KA, Yeh CC, Chiang TL, Ko TL, Chiu MM, Chen CF. Xenograft of Human Umbilical Mesenchymal Stem Cells from Wharton’s Jelly differentiating into osteocytes and reducing the osteoclasts activity Reverses Osteoporosis in Ovariectomized Rats. 2018 Cell Transplantation. 27(1) : 194- 208. (第一作者)
  5. Fan YP, Hsia CC, Tseng KW, Liao CK, Fu TW, Ko TL, Chiu MM, Shih YH, Huang PY, Yang CC, Fu YS*. The Therapeutic Potential of Human Umbilical Mesenchymal Stem Cells from Wharton's Jelly in the Treatment of Rat Peritoneal Dialysis-Induced Fibrosis. 2016 Stem Cell Translational Medicine 5:235- 247. (通訊作者)
  6. Huang PY, Shih YH, Tseng YJ, Ko TL, Fu YS*, Lin YY*. Xenograft of Human Umbilical Mesenchymal Stem Cells for the Rat Pilocarpine-Induced Epilepsy. 2016 Brain, Behavior, and Immunity 54: 45-58. (共同通訊作者)
  7. Ko TL, Fu YY, Shih YH, Lin YH, Ko MH, Fu TW, Lin TY, Hsiao HS, Chu PM*, Fu YS*. A High Efficiency Induction of Dopaminergic Cells from Human Umbilical Mesenchymal Stem Cells for the Treatment of Hemiparkinsonian Rats. 2015 Cell Transplantation. 24: 2251- 2262. (通訊作者)
  8. Wang HY, Kuo ZC, Fu YS, Chen RF, Min MY, Yang HW. GABAB receptor-mediated tonic inhibition regulates the spontaneous firing of locus coeruleus neurons in developing rats and in citalopram-treated rats. 2015 J Physiol 593(1): 161- 180.
  9. Tseng FW, Tsai MJ, Yu LY, Fu YS*, Huang WC*, Cheng H*. Comparative effects of bone marrow mesenchymal stem cells on lipopolysaccharide-induced microglial activation. 2013 Oxid Med Cell Longev. Volume 2013, Article ID 234179, 10 pages. (共同通訊作者)
  10. Tsai MJ, Ho PJ, Lin YL, Huang MC, Lee MJ, Liou DY, Huang WC, Fu YS*, Cheng H*. Microglia-conditioned medium promotes locomotor recovery and neuroprotection after rat spinal cord injury. 2012 Advances in Bioscience and Biotechnology, 3: 524-530.(共同通訊作者)
  11. Lin YC, Ko TL, Shih YH, Fu TW, Hsiao HS, Hsu JY C.*, Fu YS*. Human umbilical mesenchymal stem cells promote recovery after ischemic stroke. 2011 Stroke. 42: 2045-2053. (共同通訊作者)
  12. Hsieh JY, Fu YS, Chang SJ, Tsuang YH and Wang HW. Functional module analysis reveals differential osteogenic and stemness potentials in human mesenchymal stem cells from bone marrow and Wharton’s jelly of umbilical cord. 2010 Stem Cells and Development. 19(12): 1-16.
  13. Shih YT, Cheng YC, Yang CC, Fu YS*. Potential Application of Human Umbilical Cord Mesenchymal Stem Cells for the Treatment of Neurological Diseases. 2010 Formosan Journal of Medicine. 14(5): 531-545.( 通訊作者)
  14. Tsai PC, Fu TW, Chen YM A, Ko TL, Chen TH, Shih YH, Hung SC*, Fu YS*. The Therapeutic Potential of Human Umbilical Mesenchymal Stem Cells from Wharton's Jelly in the Treatment of Rat Liver Fibrosis. 2009 Liver Transplantation. 15: 484-495. (通訊作者)
  15. Fu YS*, Lin YY, Chou SC, Tsai TH, Kao LS, Hsu SY, Cheng FC, Shih YH, Cheng H, Fu YY, Wang JY. Tetramethylpyrazine Inhibits Activities of Glioma Cells and Glutamate Neuro-excitotoxicity - Potential Therapeutic Application for Treatment of Glioma. 2008 Neuro-Oncology. 10(2): 139- 152. (通訊作者)
  16. Yang CC, Shih YH, Ko MH, Hsu SY, Cheng H, Fu YS*. Transplantation of Human Umbilical Mesenchymal Stem Cells from Wharton's Jelly after Complete Transection of the Rat Spinal Cord. 2008 PLoS ONE 3(10): e3336. (通訊作者)
  17. Chao KC, K Chao F, Fu YS, SH Liu*. Islet-Like Clusters Derived from Mesenchymal Stem Cells in Wharton’s Jelly of the Human Umbilical Cord for Transplantation to Control Type 1 Diabetes. 2008 PLoS ONE 3(1): e1451. (共同第一作者)
  18. Chang CF, Hsu KH, Chiou SH, Ho L LT, Fu YS*, Hung SC*. Fibronectin and pellet suspension culture promote differentiation of human mesenchymal stem cells into insulin producing cells. 2008 J Biomed Materials Research Part A. 86(4):1097-1105. (通訊作者)
  19. Chou SC, Ko TL, Fu YY, Wang HW*, Fu YS*. Identification of Genetic Networks during Mesenchymal Stem Cell Transformation into Neuron.2008 Chinese J. Physiology. 51(4): 230-246. (共同通訊作者)
  20. Fu YS*, Cheng YC, Lin MY A, Cheng H, Chu PM, Chou SC, Sung MS, Shih YH. Conversion of Human Umbilical Cord Mesenchymal Stem Cells in Wharton’s Jelly to Dopaminergic Neurons in Vitro - Potential Therapeutic Application for Parkinsonism. 2006 Stem Cells 24: 115-124. (通訊作者)

Invited Presentations

  • 2018/12/07~12/09
    - Invited 中國-東盟衰老疾病與疾病學術論壇、大會演講
    - The potential Application of human umbilical mesenchymal stem cells in regenerative medicine.
  • 2018/10/13
    - Invited 福爾摩沙獸醫師年會
    - 人類臍帶間質幹細胞的可塑性與其臨床治療潛能.
  • 2018/05/27
    - Invited 中國吉林省幹細胞年會、大會演講
    - The plasticity of human umbilical mesenchymal stem cells and their diversity of therapeutic strategies.
  • 2015/08/08
    - Invited 中国解剖学会
    - 人類臍帶間質幹細胞在臨床醫學上的治療潛能.
  • 2014/09/24
    - Invited 岑祥股份有限公司/蛋白質研究新知研討會
    - 人類臍帶間質幹細胞在臨床醫學上的治療潛能.
  • 2008/06/28
    - Invited 中華醫學會
    - The Therapeutic Potential of the Human Umbilical Mesenchymal Stem Cells in Wharton's Jelly on Treatment of Rat Liver Fibrosis Model.
  • 2007/05/06
    - Invited 中華民國血液淨化醫學會
    - 治療慢性腎衰竭的新興技術-幹細胞應用.
  • 2007/03/24
    - Invited 台灣癲癇醫學會
    - Potential Therapeutic Application of Tetramethylpyrazine for Treatment of Glioma.
  • 2006/07/29
    - Invited 臺灣神經創傷學會
    - Potential Application of Human Umbilical Cord Mesenchymal Stem Cells in Wharton’s Jelly for the treatment of Parkinsonism.
  • 2006/06/24
    - Invited 中華醫學會
    - Conversion of Human Umbilical Cord Mesenchymal Stem Cells in Wharton’s Jelly to Dopaminergic Neurons in Vitro - Potential Therapeutic Application for Parkinsonism.
  • 2004/02/20
    - Invited 國家衛生研究院幹細胞中心
    - Transplantation of dopaminergic neurons derived from human umbilical mesenchymal stem cells into striatum of hemiparkinsonian rats.

指導學生獲獎

  1. 指導研究生林詩莉,2012獲中華民國解剖學學會年度學術論文競賽碩士組、第一名。
  2. 指導研究生黃婉禎,2014獲中華民國解剖學學會年度學術論文競賽碩士組、第一名。
  3. 指導研究生張文馨,2015獲中華民國解剖學學會年度學術論文競賽碩士組、第一名。
  4. 指導研究生王詩瑤,2017獲中華民國解剖學學會年度學術論文競賽碩士組、第一名。
  5. 指導研究生黃峻暐,2018獲中華民國解剖學學會年度學術論文競賽碩士組、第一名。