Ph.D. Assistant Professor
Office: A124 # 67160
Lab: B117 # 65429,65430
Welcome to Hou’s laboratory! Our goal is to explore the mystery that establish the highly sophisticated human neocortex. In this end, we could provide a fundamental step towards both understanding and the further developing the medication of human nervous system disorders.
Three centuries ago (1664) Thomas Willis proposed that the brain is responsible for the higher cognition, which is known to be mastered by the neocortex of forebrain at present. To delicately process a huge amount of information all the time, the neocortex is divided into multiple functional areas, also called Brodmann’s area (1909). Each area exerts the unique functions, such as primary somatosensory area for receiving information and the neighboring primary motor area for order delivering. The cross-talk of cortical neurons in these areas thus helps us to process the information and deliver the orders for voluntary movements. These in turn lighten on the disorder of human nervous system may not cause death directly but lead to low quality of living. However, the limited understanding of human neocortex has hampered the development of effective medications.
To explore the mystery of human neocortical development to broaden our understanding and developing the medication for neurological disorders, we have two approaches:
- With the evolutional aspect to uncover the mechanism underlying human cortical development
Adopt 3D organoid culture system from pluripotent stem cells to mimic nervous system disorder
- Doctor of Philosophy: Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University
- JSPS Postdoctoral Fellowship 2017~2019
- Postdoctoral Researcher in CDB, RIKEN, Japan 2016~2017
- Visiting Postdoctoral Researcher in CDB, RIKEN, Japan (Supported by MOST, Taiwan)
- Postdoctoral Researcher in Academia Sinica, Taiwan 2013~2015
Honors and Awards
- 2017 JSPS Postdoctoral Fellowship
- 2015 MOST Postdoctoral Research Abroad Program
- Neocortical Development, Neural differentiation of embryonic stem cells
- Hou PS, Miyoshi G, Hanashima C. Sensory cortex wiring requires preselection of short- and long-range projection neurons through an Egr-Foxg1-COUP-TFI network. Nat Commun. 2019 Aug 8;10(1):3581.
- Hou PS, Kumamoto T, Hanashima C. A Sensitive and Versatile In Situ Hybridization Protocol for Gene Expression Analysis in Developing Amniote Brains. Methods Mol Biol. 2017;1650:319-334.
- Hou PS, Chuang CY, Yeh CH, Chiang W, Liu HJ, Lin TN, Kuo HC. Direct Conversion of Human Fibroblasts into Neural Progenitors Using Transcription Factors Enriched in Human ESC-Derived Neural Progenitors. Stem Cell Reports. 2017 Jan 10;8(1):54-68.
- Hou PS, Huang WC, Chiang W, Lin WC, Chien CL. Impaired neural differentiation potency by retinoic acid receptor-α pathway defect in induced pluripotent stem cells. Cell Reprogram. 2014 Dec;16(6):467-76.
- Lin IY, Chiu FL, Yeang CH, Chen HF, Chuang CY, Yang SY, Hou PS, Sintupisut N, Ho HN, Kuo HC, Lin KI. Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cells. Stem Cell Reports. 2014 Jan 23;2(2):189-204.
- Shetty AS, Godbole G, Maheshwari U, Padmanabhan H, Chaudhary R, Muralidharan B, Hou PS, Monuki ES, Kuo HC, Rema V, Tole S. Lhx2 regulates a cortex-specific mechanism for barrel formation. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4913-21.
- Hou PS, Chuang CY, Kao CF, Chou SJ, Stone L, Ho HN, Chien CL, Kuo HC. LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1. Nucleic Acids Res. 2013 Sep;41(16):7753-70.
- Wong CW, Hou PS, Tseng SF, Chien CL, Wu KJ, Chen HF, Ho HN, Kyo S, Teng SC. Krüppel-like transcription factor 4 contributes to maintenance of telomerase activity in stem cells. Stem Cells. 2010 Sep;28(9):1510-7.
- Chen YT, Furushima K, Hou PS, Ku AT, Deng JM, Jang CW, Fang H, Adams HP, Kuo ML, Ho HN, Chien CL, Behringer RR. PiggyBac transposon-mediated, reversible gene transfer in human embryonic stem cells. Stem Cells Dev. 2010 Jun;19(6):763-71.