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師資簡介Faculty

鄭瓊娟照片
鄭瓊娟教授(兼所長科主任)

Chung Jiuan Jeng, Ph.D. Professor

辦公室 A128 # 67072

實驗室 A117,A119 # 65439,65440

cjjeng@nycu.edu.tw

實驗室介紹

歡迎來到我們的實驗室!我們目前有兩個研究方向:(1)離子通道疾病,(2)神經發炎的訊息機制。藉由了解疾病的病生理機制,期待未來可以研發出預防及治療這些疾病的方式。

實驗室研究方向

神經細胞有許多不同種類的電位控制鉀離子通道,這些鉀離子通道是設定細胞膜興奮性、設定細胞活化頻率、型塑動作電位波形和調控神傳導物質及荷爾蒙分泌等功能所必需的。目前實驗室的研究結合了分子生物學、生物化學、細胞生物學和電生理等技術,探討離子通道的構造與功能,研究離子通道蛋白質生合成與降解的衡定調控機制,及研究離子通道突變引發神經系統疾病的分子機制等。我們主要研究方向之一是探討ether-á-go-go(Eag)鉀離子通道的構造與功能,並藉著研究與疾病相關的Eag1和hErg突變蛋白質的衡定調控,以了解EAG鉀離子通道在神經細胞的正常生理與病生理角色。另一研究方向的主角是Kv4鉀離子通道,主要探討和脊髓小腦性共濟失調症(SCA19/22)相關之Kv4.3突變蛋白質的分子特徵,研究SCA19/22相關的Kv4.3突變蛋白質對正常型蛋白質造成的影響,包括如何影響正常型Kv4.3蛋白質的合成、降解、膜運輸、電壓依賴門控等的分子機制。除了與多位老師合作探討細胞內訊息傳遞路徑,本實驗室也參與在學校的腦科學中心的研究團隊中,利用培養的神經細胞與基因剔除小鼠,以分生和細胞生物學的方法,結合免疫螢光染色和共軛焦顯微鏡的觀察,研究神經細胞中分子的分布和變化,探討影響神經細胞生長、死亡、興奮性的因子,及神經細胞受到傷害時的保護機制等。


教師資訊

鄭瓊娟教授(兼所長科主任)

現職

  • 陽明交通大學解剖學及細胞生物學科暨研究所教授

學歷

  • 加州大學洛杉磯分校解剖學及細胞生物學研究所博士
  • 臺灣大學醫學院解剖學研究所碩士
  • 臺灣大學醫學院物理治療學系學士

經歷

  • 輔仁大學醫學系助理教授
  • 台醫生物科技公司研究員
  • 美國加州理工學院博士後研究員
  • 美國加州大學洛杉磯分校博士後研究員
  • 臺灣大學醫學院解剖學研究所助教

重要獎項與榮譽

  • 陽明大學106學年度校級教學優良獎
  • 陽明大學100學年度醫學院教學優良琉璃獎座
  • 陽明大學97學年度校級教學優良獎

研究專長

  • 離子通道、細胞生物學、神經科學


發表論文

  1. C.-T. Hsiao., T.F. Tropea., S.-J. Fu, T.M. Bardakjian, P. Gonzalez-Alegre, B.-W. Soong, C.-Y. Tang*, C.-J. Jeng* (2021) Rare gain-of-function KCND3 variant associated with cerebellar ataxia, parkinsonism, cognitive dysfunction, and brain iron accumulation. International Journal of Molecular Sciences. 22, 8247. doi: 10.3390/ijms22158247.
  2. S.-J. Fu., M.-C. Hu, C.-T. Hsiao, A.-T. Cheng, T.-Y. Chen, C.-J. Jeng*, and C.-Y. Tang* (2021) Regulation of ClC-2 chloride channel proteostasis by molecular chaperones: correction of leukodystrophy-associated defect. International Journal of Molecular Sciences. 22, 5859. doi: 10.3390/ijms22115859.
  3. G. Zanni*, C.-T. Hsiao, S.-J. Fu, C.-Y. Tang, A. Capuano, L. Bosco, F. Graziola, E. Bellacchio, S.. Servidei., G. Primiano., B.-W. Soong and C.-J. Jeng* (2021) Novel KCND3 variant underlying nonprogressive congenital ataxia or SCA19/22 disrupt Kv4.3 protein expression and K+ currents with variable effects on channel properties. International Journal of Molecular Sciences. 22, 4986. doi: 10.3390/ijms22094986.
  4. Y.-C. Fang., S.-J. Fu., P.-H. Hsu., P.-T. Chang, J.-J. Huang, Y.-C. Chiu., Y.-F. Liao, G.-M. Jow, C.-Y. Tang*, and C.-J. Jeng* (2021) Identification of MKRN1 as a second E3 ligase for Eag1 potassium channels reveals regulation via differential degradation. Journal of Biological Chemistry 296, 100484.
  5. C.-S. Chiang., S.-J. Fu., C.-L. Hsu, C.-J. Jeng, C.-Y. Tang, Y.-S. Huan, S.-C. Tang* (2021) Neuronal exosomes secreted under oxygen-glucose deprivation/reperfusion presenting differentially expressed miRNAs and affecting neuronal survival and neurite outgrowth. NeuroMolecular Medicine. doi: 10.1007/s12017-020-08641-z.
  6. S.-J. Fu, M.-C. Hu, Y.-J. Peng, H.-Y. Fang, C.-T. Hsiao, T.-Y. Chen, C.-J. Jeng*, C.-Y. Tang* (2020) CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy. Cells 9, 1332; doi:10.3390/cells9061332
  7. C.-J. Jeng, S.-J. Fu, C.-Y. You, Y.-J. Peng, C.-T. Hsiao, T.-Y. Chen, C.-Y. Tang* (2020) Defective gating and proteostasis of human CLC-1 chloride channel: molecular pathophysiology of myotonia congenital. Frontiers in Neurology Vol 11, Article 76; Doi: 10.3389/fneur.2020.00076
  8. C.-T. Hsiao, S.-J. Fu, Y.-T. Liu, Y.-H. Lu, C.-Y. Zhong, C.-Y. Tang, B.-W. Soong*, C.-J. Jeng* (2019) Novel SCA19/22-associated KCND3 mutations disrupt human KV4.3 protein biosynthesis and channel gating. Human Mutation 40:2088–2107. doi: 10.1002/humu.23865
  9. Y.-J. Peng, Y.-C. Lee, S.-J. Fu, Y.-C. Chien, Y.-F. Liao, T.-Y. Chen, C.-J. Jeng*, C.-Y. Tang* (2018) FKBP8 enhances protein stability of CLC-1 chloride channel at the plasma membrane. International Journal of Molecular Sciences. 9: 3783, doi:10.3390/ijms19123783
  10. P.-H. Hsu, Y.-T. Ma, Y.-C. Fang, J.-J. Huang, Y.-L. Gan, P.-T. Chang, G.-M. Jow, C.-Y. Tang*, C.-J. Jeng* (2017) Cullin 7 mediates proteasomal and lysosomal degradations of rat Eag1 potassium channels. Scientific Reports 7:40825, DOI: 10.1038.
  11. S.-J. Fu, C.-J. Jeng, C.-H. Ma, Y.-J. Peng, C.-M. Lee, Y.-C. Fang, Y.-C. Lee, S.-C. Tang, M.-C. Hu, C.-Y. Tang* (2017) Ubiquitin ligase RNF138 promotes episodic ataxia type 2-associated aberrant degradation of human CaV2.1 (P/Q-type) calcium channels.  Journal of Neuroscience 37(9):2485–2503.
  12. P.-H. Hsu, Y.-C. Chiu, T.-F. Lin, C.-J. Jeng* (2016) Ca2+-binding protein centrin 4 is a novel binding partner of rat Eag1 K+ channels. FEBS Open Bio doi:10.1002/2211-5463.12045.
  13. Y.-C. Teng, C.-J. Jeng, H.-J. Huang, A. M.-Y. Lin (2015) Role of autophagy in arsenite-induced neurotoxicity: The involvement of alpha-synuclein. Toxicology Letters 233: 239-245.
  14. T.-F. Lin, G.-M Jow, H.-Y. Fang, S.-J. Fu, H.-H. Wu, M.-M. Chiu, C.-J. Jeng* (2014) The eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels. PLoS ONE 9(10): e110423.
  15. T.-F. Lin, I-W. Lin, S.-C. Chen, H.-H. Wu, C.-S. Yang, H.-Y Fang, M.-M. Chiu, C.-J. Jeng* (2014) The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains. Journal of Biological Chemistry 289(33):22815-22834.
  16. C.-C. Chuang, G.-M. Jow, H.-M. Lin, Y.-H. Weng, J.-H. Hu, Y.-J. Peng, Y.-C. Chiu, M.-M. Chiu, C.-J. Jeng* (2014) The punctate localization of rat Eag1 K+ channels. BMC Neuroscience 15:23.
  17. C.-K. Liao, C.-J. Jeng, H.-S. Wang, S.-H. Wang, J.C. Wu (2013) Lipopolysaccharide induces degradation of connexin43 in rat astrocytes via the ubiquitin-proteasome proteolytic pathway.  PLoS ONE 8(11): e79350.
  18. P.-H. Hsu, S.-C. Miawa, C.-C. Chuang, P.-Y. Chang, S.-J. Fu, G.-M. Jow, M.-M. Chiu, C.-J. Jeng* (2012) 14-3-3theta is a Binding Partner of Rat Eag1 potassium Channels. PLoS ONE 7(7): e41203.
  19. S.-H. Yang, C.-C. Liao, Y. Chen, J.-P. Syu, C.-J. Jeng*, S.-M. Wang (2012) Daidzein induces neuritogenesis in DRG neuronal cultures. Journal of Biomedical Science 19:80.
  20. I.-H. Chen, J.-H. Hu, G.-M. Jow, C.-C. Chuang, T.-T. Lee, D.-C. Liu, C.-J. Jeng* (2011) The distal end of carboxyl-terminus is not essential for the assembly of rat Eag1 potassium channels.  Journal of Biological Chemistry 286(31) 27183–27196.
  21. S.-H. Yang; C.-J. Jeng, C-H Chen, Y. Chen, Y.-C. Chen, and S.-M. Wang* (2011) Schisandrin enhances dendrite outgrowth and synaptogenesis in primary cultured hippocampal neurons.  Journal of the Science of Food and Agriculture 91(4): 694–702.

受邀演講

  1. Proteostatic Mechanism of Eag1 Potassium Channel, 29th Ion Channel Meeting, CANAUX IONIQUES, Sète, France, 9/10/2018.
  2. Regulation of ether-à-go-go potassium channel expression by RING E3 ubiquitin ligases and 14-3-3 proteins, 政治大學神經科學研究所,5/22/2018.
  3. Regulation of Ether-à-go-go Potassium Channel Expression by RING E3 Ubiquitin Ligases, The 33th Joint Annual Conference of Biomedical Science, Taipei, Taiwan, 3/24/2018.
  4. Protein Interaction Mechanisms of EAG Potassium Channels, Internal Symposium in Osaka University, Osaka, Japan, 8/3/2017.
  5. Protein Targeting and Molecular Assembly of Ether-à-go-go Potassium Channels, The 31th Joint Annual Conference of Biomedical Science, Taipei, Taiwan, 3/26/2016.
  6. Molecular Assemblyof Ether-a-go-go Potassium Channels, 陽明大學生理所,3/19/2015.
  7. Molecular Assembly and Protein Association of Ether-a-go-go Potassium Channels, 高雄榮民總醫院 教研部,10/31/2014.
  8. Molecular Assembly and Protein Association of EAG K+ Channels, 生科院-週三中午有約,6/5/2013.
  9. Structural and functional characterization of ether-à-go-go potassium channel, 輔仁大學基礎醫學研究所,11/29/2012.
  10. Molecular assembly and protein association of neuronal potassium channels,The 26th Joint Annual Conference of Biomedical Sciences ,3/20/2011.
  11. When Good Proteins Meet Bad Proteins: Dominant Negative Effects of Calcium Channel Mutations, 臺北醫學大學/神經科學研究第四十六次月會,11/30/2007.