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師資簡介Faculty

鄭瓊娟照片
鄭瓊娟教授(兼所長科主任)

Chung Jiuan Jeng, Ph.D. Professor

辦公室 A128 # 7072

實驗室 A117,A119 # 5439,5440

cjjeng@ym.edu.tw

實驗室介紹

歡迎來到我們的實驗室!我們目前有兩個研究方向:(1)離子通道疾病,(2)神經發炎的訊息機制。藉由了解疾病的病生理機制,期待未來可以研發出預防及治療這些疾病的方式。

實驗室研究方向

神經細胞有許多不同種類的電位控制鉀離子通道,這些鉀離子通道是設定細胞膜興奮性、設定細胞活化頻率、型塑動作電位波形和調控神傳導物質及荷爾蒙分泌等功能所必需的。目前實驗室的主要研究方向,是結合了細胞生物學、生物化學、和分子生物學等技術,從不同的角度研究ether-à-go-go(EAG)鉀離子通的構造與功能,及蛋白質的生合成與降解的衡定調控分子機制。並藉著研究與疾病相關的Eag1和hErg突變蛋白質的衡定調控,以了解EAG鉀離子通道在神經細胞的正常生理與病生理角色。 除了與多位所內外老師合作探討細胞內訊息傳遞路徑,本實驗室也參與在學校的腦科學中心的研究團隊中,利用培養的神經細胞與基因剔除小鼠,以分生和細胞生物學的方法,結合免疫螢光染色和共軛焦顯微鏡的觀察,研究神經細胞中分子的分布和變化,探討影響神經細胞生長、死亡、興奮性的因子,及神經細胞受到傷害時的保護機制等。

教師資訊

鄭瓊娟教授(兼所長科主任)

現職

  • 陽明大學解剖學及細胞生物學科暨研究所教授

學歷

  • 加州大學洛杉磯分校解剖學及細胞生物學研究所博士
  • 臺灣大學醫學院解剖學研究所碩士
  • 臺灣大學醫學院物理治療學系學士

經歷

  • 輔仁大學醫學系助理教授
  • 台醫生物科技公司研究員
  • 美國加州理工學院博士後研究員
  • 美國加州大學洛杉磯分校博士後研究員
  • 臺灣大學醫學院解剖學研究所助教

重要獎項與榮譽

  • 陽明大學106學年度校級教學優良獎
  • 陽明大學100學年度醫學院教學優良琉璃獎座
  • 陽明大學97學年度校級教學優良獎

研究專長

離子通道、神經科學

發表論文

  1. C.-T. Hsiao, S.-J. Fu, Y.-T. Liu, Y.-H. Lu, C.-Y. Zhong, C.-Y. Tang, B.-W. Soong*, C.-J. Jeng* (2019) Novel SCA19/22-associated KCND3 mutations disrupt human KV4.3 protein biosynthesis and channel gating. Human Mutation 40:2088–2107.
  2. Y.-J. Peng, Y.-C. Lee, S.-J. Fu, Y.-C. Chien, Y.-F. Liao, T.-Y. Chen, C.-J. Jeng*, C.-Y. Tang* (2018) FKBP8 enhances protein stability of CLC-1 chloride channel at the plasma membrane. International Journal of Molecular Sciences. 9: 3783, doi:10.3390/ijms19123783
  3. P.-H. Hsu, Y.-T. Ma, Y.-C. Fang, J.-J. Huang, Y.-L. Gan, P.-T. Chang, G.-M. Jow, C.-Y. Tang*, and C.-J. Jeng* (2017) Cullin 7 mediates proteasomal and lysosomal degradations of rat Eag1 potassium channels. Scientific Reports 7:40825, DOI: 10.1038.
  4. S.-J. Fu, C.-J. Jeng, C.-H. Ma, Y.-J. Peng, C.-M. Lee, Y.-C. Fang, Y.-C. Lee, S.-C. Tang, M.-C. Hu, and C.-Y. Tang* (2017) Ubiquitin ligase RNF138 promotes episodic ataxia type 2-associated aberrant degradation of human CaV2.1 (P/Q-type) calcium channels. Journal of Neuroscience 37(9):2485–2503.
  5. P.-H. Hsu, Y.-C. Chiu, T.-F. Lin, and C.-J. Jeng* (2016) Ca2+-binding protein centrin 4 is a novel binding partner of rat Eag1 K+ channels. FEBS Open Bio doi:10.1002/2211-5463.12045.
  6. Y.-C. Teng, C.-J. Jeng, H.-J. Huang, A. M.-Y. Lin (2015) Role of autophagy in arsenite-induced neurotoxicity: The involvement of alpha-synuclein. Toxicology Letters 233: 239-245.
  7. T.-F. Lin, G.-M Jow, H.-Y. Fang, S.-J. Fu, H.-H. Wu, M.-M. Chiu, and C.-J. Jeng* (2014) The eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels. PLoS ONE 9(10): e110423.
  8. T.-F. Lin, I-W. Lin, S.-C. Chen, H.-H. Wu, C.-S. Yang, H.-Y Fang, M.-M. Chiu, and C.-J. Jeng* (2014) The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains. Journal of Biological Chemistry 289(33):22815-22834.
  9. C.-C. Chuang, G.-M. Jow, H.-M. Lin, Y.-H. Weng, J.-H. Hu, Y.-J. Peng, Y.-C. Chiu, M.-M. Chiu, C.-J. Jeng* (2014) The punctate localization of rat Eag1 K+ channels. BMC Neuroscience 15:23.
  10. C.-K. Liao, C.-J. Jeng, H.-S. Wang, S.-H. Wang, J.C. Wu (2013) Lipopolysaccharide induces degradation of connexin43 in rat astrocytes via the ubiquitin-proteasome proteolytic pathway. PLoS ONE 8(11): e79350.
  11. P.-H. Hsu, S.-C. Miawa, C.-C. Chuang, P.-Y. Chang, S.-J. Fu, G.-M. Jow, M.-M. Chiu, C.-J. Jeng* (2012) 14-3-3theta is a Binding Partner of Rat Eag1 potassium Channels. PLoS ONE 7(7): e41203.
  12. S.-H. Yang, C.-C. Liao, Y. Chen, J.-P. Syu, C.-J. Jeng*, and S.-M. Wang (2012) Daidzein induces neuritogenesis in DRG neuronal cultures. Journal of Biomedical Science 19:80.
  13. I.-H. Chen, J.-H. Hu, G.-M. Jow, C.-C. Chuang, T.-T. Lee, D.-C. Liu, and C.-J. Jeng* (2011) The distal end of carboxyl-terminus is not essential for the assembly of rat Eag1 potassium channels. Journal of Biological Chemistry 286(31) 27183–27196.
  14. Y.-P. Lai, C.-J. Jeng, and S.-C. Chen (2011) The roles of CD4+ T cells in tumor immunity. ISRN Immunology Volume 2011, Article ID 497397, 6 pages.
  15. S.-H. Yang; C.-J. Jeng, C-H Chen, Y. Chen, Y.-C. Chen, and S.-M. Wang (2011) Schisandrin enhances dendrite outgrowth and synaptogenesis in primary cultured hippocampal neurons. Journal of the Science of Food and Agriculture 91(4): 694–702.
  16. J.-Y. Deng, S.-J. Chen, G.-M. Jow, C.-W. Hsueh, and C.-J. Jeng* (2009) Dehydroeburicoic acid induces calcium- and calpain-dependent necrosis in human U87MG glioblastomas. Chemical Research Toxicology 22, 1817–1826.
  17. G.-M. Jow and C.-J. Jeng* (2008) Differential localization of rat Eag1 and Eag2 potassium channels in the retina. Neuroscience Letters 24; 431(1):12-6.
  18. Y.-C. Lien, H.-N. Kung, K.-S. Lu*, C.-J. Jeng*, Y.-P. Chau (2008) Involvement of endoplasmic reticulum stress and activation of MAP kinases in beta-lapachone-induced human prostate cancer cell apoptosis. Histology and Histopathology. 23(11):1299-308.
  19. P. Wang, C.-J. Jeng, C.-L., Chien S.-M. Wang (2008) Signaling mechanisms of daidzein-induced axonal outgrowth in hippocampal neurons. Biochemical and Biophysical Research Communications 338:1417-1425.
  20. C.-J. Jeng, M.-C. Sun, Y.-W. Chen, and C.-Y. Tang (2008) Dominant-negative effects of episodic ataxia type 2 mutations involve disruption of membrane trafficking of human P/Q-type Ca2+ channels. Journal of Cellular Physiology 214(2):422-33.
  21. S.-H. Yang, Y.-J. Chen, P.-Y. Tung, W.-L. Lai, Y Chen, C.-J. Jeng*, and S.-M. Wang (2008) Anti-Thy-1 antibody-induced neurite outgrowth in cultured dorsal root ganglionic neurons is mediated by the c-Src-MEK signaling pathway. Journal of Cellular Biochemistry 103(1):67-77.
  22. C.-H. Chen, Y.-J. Chen, C.-J. Jeng, S.-H. Yang, and S.-M. Wang (2007) Role of PKA in Thy-1 antibody-induced neurite outgrowth in dorsal root ganglionic neurons. Journal of Cellular Biochemistry 101(3):566-575.
  23. C.-J. Jeng, Y.-T. Chen, Y.-W. Chen, and C.-Y. Tang (2006) Dominant-negative effects of human P/Q-type Ca2+ channel mutations associated with episodic ataxia type 2. Am. J. Physiol. Cell Physiol 290: C1209–C1220.
  24. J.-H. Yeh, C.-J. Jeng, Y.-W. Chen, H.-M. Lin, Y.-S. Wu, and C.-Y. Tang (2005) Selective enhancement of tonic inhibition by increasing ambient GABA is insufficient to suppress excitotoxicity in hippocampal neurons. Biochem. Biophys. Res. Commun. 338, 1417-1425
  25. C.-Y. Tang, Y.-W. Chen, G.-M. Jow, C.-J. Chou, and C.-J. Jeng* (2005) Beauvericin activates Ca2+-activated Cl- currents and induces cell deaths in Xenopus oocytes via influx of extracellular Ca2+. Chem Res Toxicol 18: 825-833.
  26. L.-J. Yang, C.-J. Jeng, H.-N. Kung, C.-C. Chang, A.-G. Wang, G.-Y. Chau, M.-J. Don, Y.-P. Chau (2005) Tanshinone IIA isolated from Salvia miltiorrhiza elicits the cell death of human endothelial cells. J. Biomed. Sci. 12: 347-361.
  27. C.-J. Jeng, C.-C. Chang, and C.-Y. Tang (2005) Differential localization of rat Eag1 and Eag2 K+ channels in hippocampal neuron. Neuroreport 16:229-233.
  28. C.-H. Chen, S.-M. Wang, S.-H. Yang, and C.-J. Jeng* (2005) Role of Thy-1 in in vivo and in vitro neural development and regeneration of dorsal root ganglionic Neurons. J. Cell Biochem 94(4):684-94.
  29. S.-C. Chen, C.-C. Huang, C.-C. Chien, C.-J. Jeng, H.-T. Su, E. Chiang, M.-R. Liu, H. Wu, C.-N. Chang, and R.-H. Lin* (2004) Cross-linking of P-selectin glycoprotein ligand-1 induces death of activated T cells. Blood 104(10): 3233-3242.
  30. R.S. Walikonis, A. Oguni, E.M. Khorosheva, C.-J. Jeng, F.J. Asuncion, and M.B. Kennedy (2001) Densin-180 forms a ternary complex with the a-subunit of CaMKII and a–actinin. J. Neurosci. 21(2): 423-422.
  31. C.-J. Jeng, S. McCarroll, T.F. Martin, E. Floor, J. Adams, D. Krantz, S. Butz, R Edwards, and E.S. Schweitzer (1998) Thy-1 is a component common to multiple populations of synaptic vesicles. J. Cell Biol. 140, 685-698.

受邀演講

  1. Proteostatic Mechanism of Eag1 Potassium Channel, 29th Ion Channel Meeting, CANAUX IONIQUES, Sète, France, 9/11/2018.
  2. Regulation of Ether-à-go-go Potassium Channel Expression by RING E3 Ubiquitin Ligases, The 33th Joint Annual Conference of Biomedical Science, Taipei, Taiwan, 3/24/2018.
  3. Protein Interaction Mechanisms of EAG Potassium Channels, Internal Symposium in Osaka University, Osaka, Japan, 8/3/2017.
  4. Protein Targeting and Molecular Assembly of Ether-à-go-go Potassium Channels, The 31th Joint Annual Conference of Biomedical Science, Taipei, Taiwan, 3/26/2016.