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師資簡介Faculty

鄭瓊娟照片
鄭瓊娟教授(兼所長科主任)

Chung Jiuan Jeng, Ph.D. Professor

辦公室 A128 # 7072

實驗室 A117,A119 # 5439,5440

cjjeng@ym.edu.tw

實驗室介紹

歡迎來到我們的實驗室!我們目前有兩個研究方向:(1)離子通道疾病,(2)神經發炎的訊息機制。藉由了解疾病的病生理機制,期待未來可以研發出預防及治療這些疾病的方式。

實驗室研究方向

神經細胞有許多不同種類的電位控制鉀離子通道,這些鉀離子通道是設定細胞膜興奮性、設定細胞活化頻率、型塑動作電位波形和調控神傳導物質及荷爾蒙分泌等功能所必需的。目前實驗室的研究結合了分子生物學、生物化學、細胞生物學和電生理等技術,探討離子通道的構造與功能,研究離子通道蛋白質生合成與降解的衡定調控機制,及研究離子通道突變引發神經系統疾病的分子機制等。我們主要研究方向之一是探討ether-á-go-go(Eag)鉀離子通道的構造與功能,並藉著研究與疾病相關的Eag1和hErg突變蛋白質的衡定調控,以了解EAG鉀離子通道在神經細胞的正常生理與病生理角色。另一研究方向的主角是Kv4鉀離子通道,主要探討和脊髓小腦性共濟失調症(SCA19/22)相關之Kv4.3突變蛋白質的分子特徵,研究SCA19/22相關的Kv4.3突變蛋白質對正常型蛋白質造成的影響,包括如何影響正常型Kv4.3蛋白質的合成、降解、膜運輸、電壓依賴門控等的分子機制。除了與多位老師合作探討細胞內訊息傳遞路徑,本實驗室也參與在學校的腦科學中心的研究團隊中,利用培養的神經細胞與基因剔除小鼠,以分生和細胞生物學的方法,結合免疫螢光染色和共軛焦顯微鏡的觀察,研究神經細胞中分子的分布和變化,探討影響神經細胞生長、死亡、興奮性的因子,及神經細胞受到傷害時的保護機制等。


教師資訊

鄭瓊娟教授(兼所長科主任)

現職

  • 陽明大學解剖學及細胞生物學科暨研究所教授

學歷

  • 加州大學洛杉磯分校解剖學及細胞生物學研究所博士
  • 臺灣大學醫學院解剖學研究所碩士
  • 臺灣大學醫學院物理治療學系學士

經歷

  • 輔仁大學醫學系助理教授
  • 台醫生物科技公司研究員
  • 美國加州理工學院博士後研究員
  • 美國加州大學洛杉磯分校博士後研究員
  • 臺灣大學醫學院解剖學研究所助教

重要獎項與榮譽

  • 陽明大學106學年度校級教學優良獎
  • 陽明大學100學年度醫學院教學優良琉璃獎座
  • 陽明大學97學年度校級教學優良獎

研究專長

離子通道、細胞生物學、神經科學

發表論文

  1. S.-J. Fu, M.-C. Hu, Y.-J. Peng, H.-Y. Fang, C.-T. Hsiao, T.-Y. Chen, C.-J. Jeng* and C.-. Tang* (2020) CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy. Cells 9, 1332; doi:10.3390/cells9061332
  2. C.-J. Jeng, S.-J. Fu, C.-Y. You, Y.-J. Peng, C.-T. Hsiao, T.-Y. Chen, C.-Y. Tang* (2020) Defective gating and proteostasis of human CLC-1 chloride channel: molecular pathophysiology of myotonia congenital. Frontiers in Neurology Vol 11, Article 76; Doi: 10.3389/fneur.2020.00076
  3. C.-T. Hsiao, S.-J. Fu, Y.-T. Liu, Y.-H. Lu, C.-Y. Zhong, C.-Y. Tang, B.-W. Soong*, C.-J. Jeng* (2019) Novel SCA19/22-associated KCND3 mutations disrupt human KV4.3 protein biosynthesis and channel gating. Human Mutation 40:2088–2107.
  4. Y.-J. Peng, Y.-C. Lee, S.-J. Fu, Y.-C. Chien, Y.-F. Liao, T.-Y. Chen, C.-J. Jeng*, C.-Y. Tang* (2018) FKBP8 enhances protein stability of CLC-1 chloride channel at the plasma membrane. International Journal of Molecular Sciences. 9: 3783, doi:10.3390/ijms19123783
  5. P.-H. Hsu, Y.-T. Ma, Y.-C. Fang, J.-J. Huang, Y.-L. Gan, P.-T. Chang, G.-M. Jow, C.-Y. Tang*, and C.-J. Jeng* (2017) Cullin 7 mediates proteasomal and lysosomal degradations of rat Eag1 potassium channels. Scientific Reports 7:40825, DOI: 10.1038.
  6. S.-J. Fu, C.-J. Jeng, C.-H. Ma, Y.-J. Peng, C.-M. Lee, Y.-C. Fang, Y.-C. Lee, S.-C. Tang, M.-C. Hu, and C.-Y. Tang* (2017) Ubiquitin ligase RNF138 promotes episodic ataxia type 2-associated aberrant degradation of human CaV2.1 (P/Q-type) calcium channels. Journal of Neuroscience 37(9):2485–2503.
  7. P.-H. Hsu, Y.-C. Chiu, T.-F. Lin, and C.-J. Jeng* (2016) Ca2+-binding protein centrin 4 is a novel binding partner of rat Eag1 K+ channels. FEBS Open Bio doi:10.1002/2211-5463.12045.
  8. Y.-C. Teng, C.-J. Jeng, H.-J. Huang, A. M.-Y. Lin (2015) Role of autophagy in arsenite-induced neurotoxicity: The involvement of alpha-synuclein. Toxicology Letters 233: 239-245.
  9. T.-F. Lin, G.-M Jow, H.-Y. Fang, S.-J. Fu, H.-H. Wu, M.-M. Chiu, and C.-J. Jeng* (2014) The eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels. PLoS ONE 9(10): e110423.
  10. T.-F. Lin, I-W. Lin, S.-C. Chen, H.-H. Wu, C.-S. Yang, H.-Y Fang, M.-M. Chiu, and C.-J. Jeng* (2014) The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains. Journal of Biological Chemistry 289(33):22815-22834.
  11. C.-C. Chuang, G.-M. Jow, H.-M. Lin, Y.-H. Weng, J.-H. Hu, Y.-J. Peng, Y.-C. Chiu, M.-M. Chiu, C.-J. Jeng* (2014) The punctate localization of rat Eag1 K+ channels. BMC Neuroscience 15:23.
  12. C.-K. Liao, C.-J. Jeng, H.-S. Wang, S.-H. Wang, J.C. Wu (2013) Lipopolysaccharide induces degradation of connexin43 in rat astrocytes via the ubiquitin-proteasome proteolytic pathway. PLoS ONE 8(11): e79350.
  13. P.-H. Hsu, S.-C. Miawa, C.-C. Chuang, P.-Y. Chang, S.-J. Fu, G.-M. Jow, M.-M. Chiu, C.-J. Jeng* (2012) 14-3-3theta is a Binding Partner of Rat Eag1 potassium Channels. PLoS ONE 7(7): e41203.
  14. S.-H. Yang, C.-C. Liao, Y. Chen, J.-P. Syu, C.-J. Jeng*, and S.-M. Wang (2012) Daidzein induces neuritogenesis in DRG neuronal cultures. Journal of Biomedical Science 19:80.
  15. I.-H. Chen, J.-H. Hu, G.-M. Jow, C.-C. Chuang, T.-T. Lee, D.-C. Liu, and C.-J. Jeng* (2011) The distal end of carboxyl-terminus is not essential for the assembly of rat Eag1 potassium channels. Journal of Biological Chemistry 286(31) 27183–27196.

受邀演講

  1. Proteostatic Mechanism of Eag1 Potassium Channel, 29th Ion Channel Meeting, CANAUX IONIQUES, Sète, France, 9/11/2018.
  2. Regulation of Ether-à-go-go Potassium Channel Expression by RING E3 Ubiquitin Ligases, The 33th Joint Annual Conference of Biomedical Science, Taipei, Taiwan, 3/24/2018.
  3. Protein Interaction Mechanisms of EAG Potassium Channels, Internal Symposium in Osaka University, Osaka, Japan, 8/3/2017.
  4. Protein Targeting and Molecular Assembly of Ether-à-go-go Potassium Channels, The 31th Joint Annual Conference of Biomedical Science, Taipei, Taiwan, 3/26/2016.