跳到主要內容區塊
LOGO圖

師資簡介Faculty

王懷詩照片
王懷詩教授

Hwai-Shi Wang, Ph.D. Professor

辦公室 A116 # 7035

實驗室 A121,A123 # 5437,5438

hswang@ym.edu.tw

實驗室介紹

實驗室的研究主題包括:

  1. 乳癌細胞轉移機制。
  2. 臍帶間質幹細胞在細胞治療時的移行機制。
  3. 不同生醫材料對於幹細胞分化的影響。

教師資訊

王懷詩教授

學歷

  • 美國喬治城大學醫學院解剖學研究所博士

現職

  • 國立陽明大學解剖學及細胞生物學研究所教授

研究專長

  1. The role of CD44 in cancer metastasis.
  2. Effects of biomaterials in mesenchymal stem cell differentiation.
  3. Effect of Mesenchymal Stem Cells in rheumatoid arthritis.

發表論文

( A)期刊發表
  1. Yu-Chien Guo, Yun-Hsuan Chiu, Chie-Pein Chen and Hwai-Shi Wang. Interleukin-1β induces CXCR3-mediated chemotaxis to promote umbilical cord mesenchymal stem cell transendothelial migration. Stem Cell Research and Therapy 2018; 9:281-295 (SCI).
  2. Chen, M.-S., Lin, C.-Y. Lin, Chiu, Y.-H, Chen, C.-P., Tsai, P.-J. and Wang, H.-S.. IL-1s Induced Matrix Metalloprotease-1 Promotes Mesenchymal Stem Cell Migration via PAR1 and G-protein Coupled Signaling Pathway. Stem Cells International 2018; article ID 3524759 (SCI).
  3. Yun-Li Lin, Chie-Pein Chen, Chun-Min Lo, Hwai-Shi Wang. Stiffness-controlled three-dimensional collagen scaffolds for differentiation of human Wharton's jelly mesenchymal stem cells into cardiac progenitor cells. Journal of Biomedical Materials Research Part A 2016; 104(9):2234-2242 (SCI).
  4. Chi-Ting Chiu, Chih-Kai Liao, Chien-Chang Shen, Tswen-Kei Tang, Guey-Mei Jow, Hwai-Shi Wang, Jiahn-Chun Wu. HYS-32-Induced Microtubule Catastrophes in Rat Astrocytes Involves the PI3K-GSK3beta Signaling Pathway. PLoS One 2015; 10(5):e0126217 (SCI).
  5. Shih-Yi Kao, Jia-Fwu Shyu, Hwai-Shi Wang, Chi-Hung Lin, Cheng-Hsi Su, Tien-Hua Chen, Zen-Chung Weng and Pei-Jiun Tsai. Comparisons of Differentiation Potential in Human Mesenchymal Stem Cells from Wharton’s Jelly, Bone Marrow, and Pancreatic Tissues. Stem Cells International 2015; 29:306158 (SCI).
  6. 6. Shih-Yi Kao, Jia-Fwu Shyu, Hwai-Shi Wang, Chen-Yuan Hsiao, Cheng-Hsi Su, Tien-Hua Chen, Zen-Chung Weng, Pei-Jiun Tsai.. Transplantation of Hepatocyte-like Cells Derived from Umbilical Cord Stromal Mesenchymal Stem Cells to Treat Acute Liver Failure Rat. Journal of Biomedical Sciences 2015; 2015(7):1-9 (SCI).
  7. Chen-Yuan Hsiao, Pei-Jiun Tsai, Pei-Chun Chu, Shin-I Liu, Chia-Hsin Pan, Chie-Pein Chen, Cheng-Hsi Su, Zen-Chung, Weng, Tien-Hua Chen, Jia-Fwu Shyu, Hsiao-Huang Chang, Hwai-Shi Wang. Transplantation of Wharton's Jelly Mesenchymal Cells to Improve Cardiac Function in Myocardial Infarction Rats. Journal of Biomedical Sciences 2015; 5(1):1-12 (SCI).
  8. Pei-Jiun Tsai; Hwai-Shi Wang; Gu-Jiun Lin; Shu-Cheng Chou; Tzu-Hui Chu; Wen-Ting Chuan; Ying-Jui Lu; Zen-Chung Weng; Cheng-Hsi Su; Po-Shiuan Hsieh; Huey-Kang Sytwu; Chi-Hung Lin; Tien-Hua Chen; Jia-Fwu Shyu. Undifferentiated Wharton’s jelly mesenchymal stem cell transplantation induces insulin-producing cell differentiation and suppression of T cell-mediated autoimmunity in non-obese diabetic mice. Cell Transplantation 2015; 24(8):1555-1570 (SCI).
  9. Cheng-Yu Lin, Chia-Hua Zu, Chih-Chang Yang, Pei-Jiun Tsai, Jia-Fwu Shyu, Chie-Pein Chen, Zen-Chung Weng, Tien-Hua Chen, Hwai-Shi Wang. IL-1β-induced mesenchymal stem cell migration involves MLCK activation via PKC signaling. Cell Transplantation 2015; 24:2011-2028 (SCI).
  10. Chun-Ming Shih, Chun-Yao Huang, Li-Rung Liao, Chiao-Po Hsu, Nai-Wen Tsao, Hwai-Shi Wang, Wei-Yuan Chen, Yea-Yang Su, Shing-Jong Lin, Chun-Che Shih, Feng-Yen Lin. Nickel ions from a corroded cardiovascular stent induce monocytic cell apoptosis: Proposed impact on vascular remodeling and mechanism. Journal of Formosan Medical Association 2014; online: (SCI).
  11. Pei-Jiun Tsai, Hwai-Shi Wang, Chi-Hung Lin, Zen-Chung Weng, Tien-Hua Chen and Jia-Fwu Shyu. Intraportal injection of insulin-producing cells generated from human bone marrow mesenchymal stem cells decreases blood glucose level in diabetic rats. Endocrine Research 2014; 39(1):26-33 (SCI).
  12. Yu-Fang Huang, Chih-Kai Liao, Jau-Chen Lin, Guey-Mei Jow, Hwai-Shi Wang, Jiahn-Chun Wu. Antofine-induced connexin43 gap junction disassembly in rat astrocytes involves protein kinase Cb. NeuroToxicology 2013; 35:169-179 (SCI).
  13. Chih-Kai Liao, Chung-Jiuan Jeng, Hwai-Shi Wang, Shu-Huei Wang, Jiahn-Chun Wu. Lipopolysaccharide induces degradation of connexin43 in rat astrocytes via the ubiquitin-proteasome proteolytic pathway. Plos One 2013; 8(11):e79350 (SCI).
  14. Chih-Chang Yang, Cheng-Yu Lin, Hwai-Shi Wang, Shaw-Ruey Lyu. Matrix metalloproteases and tissue inhibitors of metalloproteinases in medial plica and pannus-like tissue contribute to knee osteoarthritis progression. Plos One 2013; 8(11):e79662 (SCI).
  15. Pei-Jiun Tsai, Hwai-Shi Wang, Yi-Ming Shyr, Zen-Chung Weng, Ling-Chen Tai, Jia-Fwu Shyu, Tien-Hua Chen. Transplantation of insulin-producing cells from umbilical cord mesenchymal stem cells for the treatment of streptozotocin-induced diabetic rats. Journal of Biomedical Science 2012; 19:47-55 (SCI).
  16. Chang-I Kung, Cheng-Yi Chen, Chih-Chang Yang, Cheng-Yu Lin, Tien-Hua Chen, Hwai-Shi Wang. Enhanced membrane-type 1 matrix metalloproteinase expression by hyaluronan oligosaccharides in breast cancer cells facilitates CD44 cleavage and tumor cell migration. Oncology Reports 2012; 28:1808-1814 (SCI).
  17. Hwai-Shi Wang, Jia-Fwu Shyu, Wen-Sheng Shen, Hsin-Chi Hsu, Torng-Chien Chi, Chie-Pein Chen, Seng-Wong Huang, Yi-Ming Shyr, Kam-Tsun Tang, Tien-Hua Chen. Transplantation of insulin producing cells derived from umbilical cord stromal mesenchymal stem cells to treat NOD mice. Cell Transplantation 2011; 20:455-466 (SCI).
  18. Jia-Fwu Shyu, Hwai-Shi Wang, Yi-Ming Shyr, Shin-E Wang, Chia-Hsiang Chen, Joo-Shin Tan, Meng-Feng Lin, Tien-Hua Chen. Alleviation of hyperglycemia in diabetic rats by intraportal injection of insulin-producing cells generated from surgically resected human pancreatic tissue. Journal of Endocrinology 2011; 208:233-244 (SCI).
  19. Hwai-Shi Wang, Pei-Yin Kuo, Chih-Chang Yang, Shaw-Ruey Lyu. Matrix metalloprotease-3 expression in the medial plica and pannus-like tissue in knees from patients with medial compartment osteoarthritis. Histopathology 2011; 58:593-600 (SCI).
  20. Chih-Kai Liao, Seu-Mei Wang, Yuh-Lien Chen, Hwai-Shi Wang, Jiahn-Chun Wu. Lipopolysaccharide-induced inhibition of connexin43 gap junction communication in astrocytes is mediated by downregulation of caveolin-3. International Journal of Biochemistry & Cell Biology 2010; 42:762-770 (SCI).
  21. Yi-Chih Kuo, Cheng-Hsi Su, Chin-Yi Liu, Tien-Hua Chen, Chie-Pein Chen, and Hwai-Shi Wang. Transforming growth factor-beta induces CD44 cleavage that promotes migration of MDA-MB-435s cells through the up-regulation of membrane type 1-matrix metalloproteinase. International Journal of Cancer 2009; 124:2568-2576 (SCI).
  22. Shu-Tine Peng, Cheng-His Su, Chun-Chi Kuo, Chen-Fu Shaw, Hwai-Shi Wang. CD44 crosslinking-mediated matrix metalloproteinase-9 relocation in breast tumor cells leads to enhanved metastasis. International Journal of Oncology 2007; 31:1119-1126 (SCI).
  23. Hwai-Shi Wang, Wen-Hsiu Tung, Kam-Tsun Tang, Yi-Kuei Wong, Ging-Jye Huang, Jiahn-Chun Wu, Yi-Jhih Guo, Chin-Chang Chen. TGF-beta induced hyaluronan synthesis in orbital fibroblasts involves protein kinase C betaII activation in vitro. Journal of Cellular Biochemistry 2005; 95:256-267 (SCI).
  24. Hwai-Shi Wang, Ying Hung, Cheng-Hsi Su, Shu-Ting Peng, Yi-Jhih Guo, Ching-Yi Liu, Mei-Chun Lai, Jia-Wei Hsu. CD44 cross-linking induces integrin-mediated adhesion and transendothelial migration in breast cancer cell line by up-regulation of LFA-1 (αLβ2) and VLA-4 (α4β1). Experimental Cell Research 2005; 1:116-126 (SCI).
  25. Hwai-Shi Wang, Shih-Chieh Hung, Shu-Tine Peng, Chun-Chieh Huang, Yi-Jhih Guo, Hung-Mu Wei, Yu-Show Fu, Mei-Chun Lai, Chin-Chang Chen. Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord. Stem Cells 2004; 22:1330-1337 (SCI).
  26. Negash, S., Wang, H.-S., Gao C, D Ledee, D., Zelenka, P.. Cdk5 regulates cell-matrix and cell-cell adhesion in lens epithelial cells. Journal of Cell Science 2002; 115:2109-2117 (SCI).
  27. Gao C., Negash, S., Guo, H.T., Dolena Ledee, D., Wang, H.-S., Zelenka, P.. CDK5 regulates cell adhesion and migration in corneal epithelial cells. Molecular Cancer Research 2002; 1:12-24 (SCI).
  28. Wong, Y.-K., Tang, K.-T., Wu, J.-C., Hwang, J.-J., Wang, H.-S. Stimulation of hyaluronan synthesis by interkeukin-1 involves activation of protein kinase C beta II in fibroblasts from patients with Graves’ophthalmopathy. Journal of Cellular Biochemistry 2001; 82:58-67 (SCI).
  29. Gao, C., Negash, S., Wang, H.-S., Ledee, D., Guo, H., Russel, P., Zelenka, P.. CDK5 mediates changes in morphology and promotes apoptosis of astrocytoma cells in response to heat shock. Journal of Cell Science 2001; 114:1145-1153 (SCI).
  30. Reddy, L., Wang, H.-S., Keese, C.R., Giaever, I., and Smith, T.J.. Assessment of rapid morphological changes associated with elevated cAMP levels in human orbital fibroblasts. Experimental Cell Research 1998; 245:360-367 (SCI).
  31. Cao, H.J., Wang, H.-S., Zhang, Y., Lin, H.-Y., Phipps, R.P., and Smith, T.J.. Activation of human orbital fibroblasts through CD40 engagement results in a dramatic induction of hyaluronan synthesis and prostaglandin endoperoxide H synthase-2 expression: Insights into potential pathogenic mechanisms of thyroid-associated ophthalmopathy. Journal of Biological Chemistry 1998; 273:29615-29625 (SCI).
  32. Smith, T.J., Sempowski, G.D., Berneson, C.S., Cao, H.J., Wang, H.-S., and Phipps, R.P.. Human thyroid fibroblasts exhibit a distinctive phenotype in culture: characteristic ganglioside profile and functional CD40 expression. Endocrinology 1997; 138:5576-5588 (SCI).
  33. Smith, T.J., Piscatelli, J.J., Andersen, V., Wang, H.S., Lance, P.. n-Butyrate induces plasminogen activator inhibitor type 1 messenger RNA in cultured Hep G2 cells 23:866-871. Hepatology 1996; 23:866-871 (SCI).
  34. Wang, H.-S., Winn, V.D., Rezanka, L.J., Cao, H.J., Frobert, Y., Sciaky, D.,Evan, C.H., Young, D.A., and Smith T.J.. Leukoregulin induction of cyclooxygenase-2 expression in human orbital fibroblasts. Journal of Biological Chemistry 1996; 271:22718-22718 (SCI).
  35. Qiao, R.-L., Wang, H.-S., Yan, W., Odekon, L.E., Del Vecchio, P.J., Smith, T.J., and Malik, A.B.. Hyaluronan synthesis in extracellular matrix is a determinant of endothelial barrier. American Journal of Physiology-Cell Physiology 1995; 269:C103-C109 (SCI).
  36. Smith, T.J., Wang, H.-S., and Evans, C.H.. Leukoregulin is a potent inducer of hyaluronan synthesis in cultured orbital fibroblasts. American Journal of Physiology-Cell Physiology 1995; 268:C382-C388 (SCI).
  37. Wang, H.-S., Keese, C.R., Giaever, I. And Smith, T.J.. Prostaglandin E2 alters human orbital fibroblast through a mechanism involving the generation of cyclic adenosine monophosphate. Journal of Clinical Endocrinology and Metabolism 1995; 80:3553-3560 (SCI).
  38. Smith, T.J., Sempowski, G.D., Wang, H.-S., Del Vecchio, P.J., Lippe, S., and Phipps, R.P.. Evidence for cellular heterogeneity in primary cultures of human orbital fibroblasts. Journal of Clinical Endocrinology and Metabolism 1995; 80:2620-2625 (SCI).
  39. Smith, T.J., Wang, H.-S., Hong, M.G., Henrikson, R.C., Keese, C.R. and Giaever, I.. Prostaglandin E2 elicits a morphological change in cultured orbital fibroblasts from patients with Graves’ophthalmopathy. Proceedings of the National Academy of Sciences of the United States of America 1994; 91:5094-5098 (SCI).
  40. Wang, H.-S., Underhill, C.B.. Hyaluronan can be non-enzymatically link to protein through an alkaline sensitive bond. Connective Tissue Research 1992; 28:29-48 (SCI).
( B)專書發表
出版年度 作者 專書/專章名稱 出版社/學術專書
2012 S.R. Lyu, D.S. Liu, C.E. Tseng, H.S. Wang and L.K. Chau (ISBN 978-953-51-0168-0)Osteoarthritis-Diagnosis, Treatment and Surgery, edited by Qian Chen Intechweb.org