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師資簡介Faculty

傅毓秀照片
傅毓秀教授

Yu-Show Fu, Ph.D. Professor

辦公室 A126 # 7254

實驗室 B122,B124 # 5415,5416

ysfu@ym.edu.tw

實驗室介紹

本實驗室為幹細胞與再生醫學研究室。 本實驗室取生產後的臍帶,分離出人類臍帶間質幹細胞,進行體外培養,再移植到不同疾病的小動物體內,探討臍帶間質幹細胞於再生醫學上的應用潛能與價值。

實驗室研究方向

人類臍帶間質幹細胞於再生醫學上的應用 臍帶為生產後的餘物,我們實驗室積極研究,存在於臍帶wharton’s jelly內的人類臍帶間質幹細胞於臨床疾病的治療效果。因此,我們建立了多種疾病的小動物模式。我們移植人類臍帶間質幹細胞於大白鼠的脊髓、大腦皮質、基底核、與海馬體內,有效治療脊髓受損、腦中風、帕金森氏症、與癲癇。我們不僅將人類臍帶間質幹細胞應用於治療中樞神經疾病,也移植人類臍帶間質幹細胞治療大白鼠的糖尿病、骨質疏鬆、肝臟纖維化、腹膜纖維化、與肺臟纖維化,都有顯著的治療效果。相關研究刊登於自由時報頭版、並接受各大電視台的專訪。

教師資訊

傅毓秀教授

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學歷

  • 國立台灣大學

現職

  • 教授

經歷

  • 國立陽明大學、解剖學及細胞生物學科、副教授
  • 國立陽明大學、解剖學及細胞生物學科、講師

重要獎項與榮譽

  • 99-106學年度醫學系網路教學評鑑之優良教師

研究專長

  1. 幹細胞與再生醫學研究室

發表論文

  1. Chu KA, Wang SY, Yeh CC, Fu TW, Fu YY, Ko TL, Chiu MM, Tsai PJ*, Fu YS*. Reversal of bleomycin-induced rat pulmonary fibrosis by a xenograft of human umbilical mesenchymal stem cells from Wharton’s jelly. 2019 Theranostics. 9(22): 6646- 6664. (通訊作者)
  2. Yeh CC, Huang WJ, Min MY, Huang TH, Ko TL, Huang PY, Wang PH, Hsu Sanford P.C., Soong BW, Fu YS*. Xenografting of Human Umbilical Mesenchymal Stem Cells from Wharton’s Jelly Ameliorates Mouse Spinocerebellar Ataxia type 1. 2019 Translational Neurodegeneration. 8(29): 1-13. (通訊作者)
  3. Hsu SPC, Wang DY, Min MY, Fu YS*. Long-Term Challenge of Methylphenidate Changes the Neuronal Population and Membrane Property of Dopaminergic Neuron in Rats. 2019 Neurochemistry International. 122: 187- 195. (通訊作者)
  4. Fu YS, Lu CH, Chu KA, Yeh CC, Chiang TL, Ko TL, Chiu MM, Chen CF. Xenograft of Human Umbilical Mesenchymal Stem Cells from Wharton’s Jelly differentiating into osteocytes and reducing the osteoclasts activity Reverses Osteoporosis in Ovariectomized Rats. 2018 Cell Transplantation. 27(1) : 194- 208. (第一作者)
  5. Fan YP, Hsia CC, Tseng KW, Liao CK, Fu TW, Ko TL, Chiu MM, Shih YH, Huang PY, Yang CC, Fu YS*. The Therapeutic Potential of Human Umbilical Mesenchymal Stem Cells from Wharton's Jelly in the Treatment of Rat Peritoneal Dialysis-Induced Fibrosis. 2016 Stem Cell Translational Medicine 5:235- 247. (通訊作者)
  6. Huang PY, Shih YH, Tseng YJ, Ko TL, Fu YS*, Lin YY*. Xenograft of Human Umbilical Mesenchymal Stem Cells for the Rat Pilocarpine-Induced Epilepsy. 2016 Brain, Behavior, and Immunity 54: 45-58. (共同通訊作者)
  7. Ko TL, Fu YY, Shih YH, Lin YH, Ko MH, Fu TW, Lin TY, Hsiao HS, Chu PM*, Fu YS*. A High Efficiency Induction of Dopaminergic Cells from Human Umbilical Mesenchymal Stem Cells for the Treatment of Hemiparkinsonian Rats. 2015 Cell Transplantation. 24: 2251- 2262. (通訊作者)
  8. Wang HY, Kuo ZC, Fu YS, Chen RF, Min MY, Yang HW. GABAB receptor-mediated tonic inhibition regulates the spontaneous firing of locus coeruleus neurons in developing rats and in citalopram-treated rats. 2015 J Physiol 593(1): 161- 180.
  9. Tseng FW, Tsai MJ, Yu LY, Fu YS*, Huang WC*, Cheng H*. Comparative effects of bone marrow mesenchymal stem cells on lipopolysaccharide-induced microglial activation. 2013 Oxid Med Cell Longev. Volume 2013, Article ID 234179, 10 pages. (共同通訊作者)
  10. Tsai MJ, Ho PJ, Lin YL, Huang MC, Lee MJ, Liou DY, Huang WC, Fu YS*, Cheng H*. Microglia-conditioned medium promotes locomotor recovery and neuroprotection after rat spinal cord injury. 2012 Advances in Bioscience and Biotechnology, 3: 524-530.(共同通訊作者)
  11. Lin YC, Ko TL, Shih YH, Fu TW, Hsiao HS, Hsu JY C.*, Fu YS*. Human umbilical mesenchymal stem cells promote recovery after ischemic stroke. 2011 Stroke. 42: 2045-2053. (共同通訊作者)
  12. Hsieh JY, Fu YS, Chang SJ, Tsuang YH and Wang HW. Functional module analysis reveals differential osteogenic and stemness potentials in human mesenchymal stem cells from bone marrow and Wharton’s jelly of umbilical cord. 2010 Stem Cells and Development. 19(12): 1-16.
  13. Shih YT, Cheng YC, Yang CC, Fu YS*. Potential Application of Human Umbilical Cord Mesenchymal Stem Cells for the Treatment of Neurological Diseases. 2010 Formosan Journal of Medicine. 14(5): 531-545.( 通訊作者)
  14. Tsai PC, Fu TW, Chen YM A, Ko TL, Chen TH, Shih YH, Hung SC*, Fu YS*. The Therapeutic Potential of Human Umbilical Mesenchymal Stem Cells from Wharton's Jelly in the Treatment of Rat Liver Fibrosis. 2009 Liver Transplantation. 15: 484-495. (通訊作者)
  15. Fu YS*, Lin YY, Chou SC, Tsai TH, Kao LS, Hsu SY, Cheng FC, Shih YH, Cheng H, Fu YY, Wang JY. Tetramethylpyrazine Inhibits Activities of Glioma Cells and Glutamate Neuro-excitotoxicity - Potential Therapeutic Application for Treatment of Glioma. 2008 Neuro-Oncology. 10(2): 139- 152. (通訊作者)
  16. Yang CC, Shih YH, Ko MH, Hsu SY, Cheng H, Fu YS*. Transplantation of Human Umbilical Mesenchymal Stem Cells from Wharton's Jelly after Complete Transection of the Rat Spinal Cord. 2008 PLoS ONE 3(10): e3336. (通訊作者)
  17. Chao KC, K Chao F, Fu YS, SH Liu*. Islet-Like Clusters Derived from Mesenchymal Stem Cells in Wharton’s Jelly of the Human Umbilical Cord for Transplantation to Control Type 1 Diabetes. 2008 PLoS ONE 3(1): e1451. (共同第一作者)
  18. Chang CF, Hsu KH, Chiou SH, Ho L LT, Fu YS*, Hung SC*. Fibronectin and pellet suspension culture promote differentiation of human mesenchymal stem cells into insulin producing cells. 2008 J Biomed Materials Research Part A. 86(4):1097-1105. (通訊作者)
  19. Chou SC, Ko TL, Fu YY, Wang HW*, Fu YS*. Identification of Genetic Networks during Mesenchymal Stem Cell Transformation into Neuron.2008 Chinese J. Physiology. 51(4): 230-246. (共同通訊作者)
  20. Fu YS*, Cheng YC, Lin MY A, Cheng H, Chu PM, Chou SC, Sung MS, Shih YH. Conversion of Human Umbilical Cord Mesenchymal Stem Cells in Wharton’s Jelly to Dopaminergic Neurons in Vitro - Potential Therapeutic Application for Parkinsonism. 2006 Stem Cells 24: 115-124. (通訊作者)

受邀演講

  • 2018/12/07~12/09
    - Invited 中國-東盟衰老疾病與疾病學術論壇、大會演講
    - The potential Application of human umbilical mesenchymal stem cells in regenerative medicine.
  • 2018/10/13
    - Invited 福爾摩沙獸醫師年會
    - 人類臍帶間質幹細胞的可塑性與其臨床治療潛能.
  • 2018/05/27
    - Invited 中國吉林省幹細胞年會、大會演講
    - Xenograft of human umbilical mesenchymal stem cells from Wharton’s jelly reverses pulmonary fibrosis in rats.
  • 2018/05/27
    - Invited 中國吉林省幹細胞年會、大會演講
    - The plasticity of human umbilical mesenchymal stem cells and their diversity of therapeutic strategies.
  • 2015/08/08
    - Invited 中国解剖学会
    - 人類臍帶間質幹細胞在臨床醫學上的治療潛能.
  • 2014/09/24
    - Invited 岑祥股份有限公司/蛋白質研究新知研討會
    - 人類臍帶間質幹細胞在臨床醫學上的治療潛能.
  • 2008/06/28
    - Invited 中華醫學會
    - The Therapeutic Potential of the Human Umbilical Mesenchymal Stem Cells in Wharton's Jelly on Treatment of Rat Liver Fibrosis Model.
  • 2007/05/06
    - Invited 中華民國血液淨化醫學會
    - 治療慢性腎衰竭的新興技術-幹細胞應用.
  • 2007/03/24
    - Invited 台灣癲癇醫學會
    - Potential Therapeutic Application of Tetramethylpyrazine for Treatment of Glioma.
  • 2006/07/29
    - Invited 臺灣神經創傷學會
    - Potential Application of Human Umbilical Cord Mesenchymal Stem Cells in Wharton’s Jelly for the treatment of Parkinsonism.
  • 2006/06/24
    - Invited 中華醫學會
    - Conversion of Human Umbilical Cord Mesenchymal Stem Cells in Wharton’s Jelly to Dopaminergic Neurons in Vitro - Potential Therapeutic Application for Parkinsonism.
  • 2004/02/20
    - Invited 國家衛生研究院幹細胞中心
    - Transplantation of dopaminergic neurons derived from human umbilical mesenchymal stem cells into striatum of hemiparkinsonian rats.

指導學生獲獎

  1. 指導研究生林詩莉,2012獲中華民國解剖學學會年度學術論文競賽碩士組、第一名。
  2. 指導研究生黃婉禎,2014獲中華民國解剖學學會年度學術論文競賽碩士組、第一名。
  3. 指導研究生張文馨,2015獲中華民國解剖學學會年度學術論文競賽碩士組、第一名。
  4. 指導研究生王詩瑤,2017獲中華民國解剖學學會年度學術論文競賽碩士組、第一名。
  5. 指導研究生黃峻暐,2018獲中華民國解剖學學會年度學術論文競賽碩士組、第一名。