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師資簡介Faculty

王先逸照片
王先逸助理教授

Sabrina Wang, Ph.D. Assistant Professor

辦公室 A120 # 7158

實驗室 A113 , A115 # 5441

sabrina@ym.edu.tw

實驗室介紹

歡迎來到我們的實驗室! 我們實驗室使用動物模式來探討憂鬱症的致病原因與腦中相關的生理與病理變化,包括下丘腦壓力反應軸、食慾素系統、與海馬迴的神經新生。近年我們也開始探討菌-腸-腦軸線及使用精神益生菌來減輕憂鬱症狀的潛力。長遠的目標是了解憂鬱症的致病原因,以發展預防方法和新的治療方式。

實驗室研究方向

使用憂鬱症動物模式來研究憂鬱症 探索致病原因及生理變化、以期研發新的治療方法

  1. 探索海馬迴神經新生與憂鬱症之關聯
  2. 胚胎發育期脂多醣干擾對子代日後壓力反應與情緒相關行為的影響
  3. 食慾素系統與憂鬱症之關聯
  4. 探索精神益生菌對憂鬱症治療之果效

教師資訊

王先逸助理教授

現職

  • 國立陽明大學助理教授

學歷

  • 1991-1997 加拿大多倫多大學生理系博士
  • 1985-1988 加拿大麥吉爾大學生物系碩士
  • 1980-1984 東海大學生物系學士

經歷

  • 國家衛生研究院助研究員

研究專長

  • 電生理、動物行為、憂鬱症研究

發表論文

  1. Wei, C. L., Wang S., Yen, J.T., Cheng, Y.F., Liao, C.L., Hsu, C.C., Wu, C.C., Tsai, Y.C. (2019) Antidepressant-like activities of live and heat-killed Lactobacillus paracasei PS23 in chronic corticosterone-treated mice and possible mechanisms. Brain Res. 1711: 202-213.
  2. Liu, C.-P., Wu, T.-H., Lin, Y.-L., Wang, S., Liu, C.-Y., Lin, S.-Y. (2016) Tailoring enzyme-like activities of gold nanoclusters by polymeric tertiary amines for protecting neurons against oxidative stress. Small 12:4127-35.
  3. Liu, W.-H., Chuang, H.-L., Huang, Y.-T., Wu, C-C., Chou, G.-T., Wang, S.*, and Tsai, Y.-C*. (2016) Alteration of behavior and monoamine levels attributable to Lactobacillus Plantarum PS128 in germ –free mice. Behav. Brain Res. 298:202-209.
  4. Liu, Y.-W., Liu, W.-H., Wu, C.-C., Juan, Y.-C., Wu, Y.-C., Tsai, H.-P., Wang, S.* and Tsai, Y.-C.* (2016) Psychotropic effects of Lactobacillus Plantarum PS128 in early life-stressed and naïve adult mice. Brain Res. 1631:1-12.
  5. Liao, T.-C., Lien, Y.-T., Wang, S., Huang, S-.L., Chen, C.-Y. (2016) Comorbidity of atopic disorders with autism spectrum disorder and attention deficit/hyperactivity disorder. J. Pediatr. 171:248-55.
  6. Wu, W.-C., Luh, D.-L., Chiang, Y.-C., Huang, C.-C., Wang, S., Wu, C.-C., Hurng, B.-S., Chang, Y.-H., Yen, L.-L., Chang, H.-Y. (2016) Reciprocal relationship between unhealthy diet and depressive symptoms from childhood to adolescence: 10-year follow-up of the Child and Adolescent Behaviors in Long-Term Evolution study. Public Health Nutri. 19:1654-65.
  7. Fang, S.-Y, Wang. S., Huang, N., Yeh, H.-H., Chen C.-Y. (2015) Prenatal Infection and Autism Spectrum Disorders in Childhood: A Population-Based Case–Control Study in Taiwan. Paediatr Perinat Epidemiol. 29:307-16.
  8. Mosa AJ, Wang S, Tan YF, Wojtowicz JM (2015) Organotypic slice cultures for studies of postnatal neurogenesis. J Vis Exp. 2015 Mar 4;(97). doi: 10.3791/52353.
  9. Lin, Y.-L. and Wang, S.* (2014) Prenatal LPS exposure increases depression-like behaviors and reduces hippocampal neurogenesis in adult rats. Behav. Brain Res. 259:24-34.
  10. Lin, Y.-L., Lin, S.-Y. and Wang, S.* (2012) Prenatal lipopolysaccharide exposure increases anxiety-like behaviors and enhances stress-induces corticosterone responses in adult rats. Brain Behav. Immun. 26:459-68.
  11. Ho, Y.-C. and Wang, S.* (2010) Adult neurogenesis is reduced in the dorsal hippocampus of rats displaying learned helplessness behavior. Neuroscience 171: 153-61.
  12. Wu, H.H. and Wang, S.* (2010) Strain differences in the chronic mild stress animal model of depression. Behav. Brain Res. 213: 94-102.
  13. Wang, S., Yan J.Y., Lo, Y.K., Carvey, P.M. and Ling, Z. (2009) Dopaminergic and serotoninergic deficiencies in young adult rats prenatally exposed to the bacterial lipopolysaccharide. Brain Res. 1265:196-204.
  14. Winocur, G., Wojtowicz, J.M., Sekeres, M., Snyder, J.S., Wang, S. (2006) Inhibition of neurogenesis interferes with hippocampus-dependent memory function. Hippocampus 16:296-304.
  15. Wang, S., Kee, N., Preston, E. and Wojtowicz, J.M.  (2004) Electrophysiological correlates of neural plasticity compensating for ischemia-induced damage in the hippocampus.  Exp. Brain Res. 165:250-260.
  16. Wang, S.; Jia, Z., Roder, J.C. and Murphy, T.H. (2002) AMPA receptor mediated miniature synaptic calcium transients in GluR2 null mice.  J. Neurophysiol. 88:29-40.
  17. Wang, S., Scott, B.W., and Wojtowicz, J.M. (2000) Heterogenous properties of dentate granule neurons in the adult rat.  J. Neurobiol. 42:248-57.

受邀演講

  1. 2017/3/26 Animal studies of the potential of psychobiotics in the treatment of major depression 中華民國解剖學學會/第31界生物醫學聯合學術年會
  2. 2013/3/23 The Potential Roles of Adult Neurogenesis and Maternal Infection in the Etiology of Major Depression中華民國解剖學學會/第28屆生物醫學聯合學術年會