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師資簡介Faculty

王先逸照片
王先逸助理教授

Sabrina Wang, Ph.D. Assistant Professor

辦公室 A120 # 67158

實驗室 A113 , A115 # 65441

sabrina@nycu.edu.tw

實驗室介紹

歡迎來到我們的實驗室! 我們實驗室使用動物模式來探討憂鬱症的致病原因與腦中相關的生理與病理變化,包括下丘腦壓力反應軸、食慾素系統、與海馬迴的神經新生。近年我們也開始探討菌-腸-腦軸線及使用精神益生菌來減輕憂鬱症狀的潛力。長遠的目標是了解憂鬱症的致病原因,以發展預防方法和新的治療方式。

實驗室研究方向

使用憂鬱症動物模式來研究憂鬱症 探索致病原因及生理變化、以期研發新的治療方法

  1. 探索海馬迴神經新生與憂鬱症之關聯
  2. 胚胎發育期脂多醣干擾對子代日後壓力反應與情緒相關行為的影響
  3. 食慾素系統與憂鬱症之關聯
  4. 探索精神益生菌對憂鬱症治療之果效

教師資訊

王先逸助理教授

現職

  • 國立陽明交通大學助理教授

學歷

  • 1991-1997 加拿大多倫多大學生理系博士
  • 1985-1988 加拿大麥吉爾大學生物系碩士
  • 1980-1984 東海大學生物系學士

經歷

  • 國家衛生研究院助研究員

研究專長

  • 電生理、動物行為、憂鬱症研究

發表論文

  1. Chung-Wei Hsu and Sabrina Wang* (2021, Dec). Changes in the Orexin System in Rats Exhibiting Learned Helplessness Behaviors. Brain Sciences,11(12):1634. NSC 104-2320-B-010-012.
  2. Yi-Fan Ma, Yi-An Lin, Chin-Lin Huang, Chih-Chieh Hsu, Sabrina Wang*, Shih‐Rung Yeh*, Ying-Chieh Tsai* (2021, Aug). Lactiplantibacillus plantarum PS128 ‐ Alleviates Exaggerated Cortical Beta Oscillations and Motor Deficits in the 6‐Hydroxydopamine Rat Model of Parkinson’s Disease. Probiotics and Antimicrobial Proteins, doi: 10.1007/s12602-021-09828-x.
  3. Liao, J. F.; Cheng, Y. F.; You, S. T.; Kuo, W. C.; Huang, C. W.; Chiou, J. J.; Hsu, C. C.; Hsieh-Li, H. M.; Wang, S*.; Tsai, Y. C.*. Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson's disease. Brain Behav Immun. 2020; 90:26-46 (SCI).
  4. Liu, T.Y., Kuo, P.H., Lu, M.L., Huang, M.C., Chen, C.H., Wu, T.H., Wang, S., Mao, W.C., Chen, H.C.. Quantifying the level of difficulty to treat major depressive disorder with antidepressants: Treatment Resistance to Antidepressants Evaluation Scale. PLoS One 2020; 15(1):e0227614 (SCI).
  5. Chia-Li Wei, Sabrina Wang, Jui-Ting Yen, Yun-Fang Cheng, Chia-Li Liao, Chih-Chieh Hsu, Chien-Chen Wu d, and Ying-Chieh Tsai. Antidepressant-like activities of live and heat-killed Lactobacillus paracasei PS23 in chronic corticosterone-treated mice and possible mechanisms. Brain Research 2019; 1711:202-213 (SCI).
  6. Liao, JF; Cheng, YF; Li, SW; Lee, WT; Hsu, CC; Wu, CC; Jeng, OJ; Wang, S; Tsai, YC. Lactobacillus plantarum PS128 ameliorates 2,5-Dimethoxy-4-iodoamphetamine-induced tic-like behaviors via its influences on the microbiota-gut-brain-axis. BRAIN RESEARCH BULLETIN 2019; 153:59-73 (SCI).
  7. Cheng, L.H., Liu, Y.W., Wu, C.C., Wang, S., Tsai, Y.C.. Psychobiotics in mental health, neurodegenerative and neurodevelopmental disorders. JOURNAL OF FOOD AND DRUG ANALYSIS 2019; 27(3):632-648 (SCI).
  8. Yen-Chin Wang, Hai-Ti Lin, Mong-Liang Lu, Ming-Chyi Huang, Chun-Hsin Chen, Tzu-Hua Wu, Sabrina Wang, Wei-Chung Mao, Po-Hsiu Kuo, Hsi-Chung Chen. The Association between the Sedative Loads and Clinical Severity Indicators in the First-onset Major Depressive Disorder . Frontiers in Psychiatry 2019; : (SCI).
  9. Liao, T.-C., Lien, Y.-T., Wang, S., Huang, S.-L., Chan, C.-Y.. Comorbidity of Atopic Disorders with Autism Spectrum Disorder and Attention Deficit/Hyperactivity Disorder. JOURNAL OF PEDIATRICS 2016; 171:248-55. (SCI).
  10. Wu, W.-C., Luh, D.-L., Chiang, Y.-C., Huang, C.-C., Wang, S., Wu, C.-C., Hurng, B.-S., Chang, Y.-H., Yen, L.-L., Chang, H.-Y.. Reciprocal relationship between unhealthy eating behaviours and depressive symptoms from childhood to adolescence: 10-year follow-up of the Child and Adolescent Behaviors in Long-Term Evolution study. Public Health Nutrition 2016; 19(9):1654-65 (SCI).
  11. Liu, C.-P., Wu, T.-H., Lin, Y.-L.., Liu, C.-Y., Wang, S., Lin, S.-Y.. Tailoring Enzyme-Like Activities of Gold Nanoclusters by Polymeric Tertiary Amines for Protecting Neurons Against Oxidative Stress. Small 2016; 12(30):4127-35 (SCI).
  12. Liu, W.-H., Chuang, H.-L., Huang, Y.-T., Wu, C-C., Chou, G.-T., Wang, S., and Tsai, Y.-C.. Alteration of behavior and monoamine levels attributable to Lactobacillus plantarum PS128 in germ –free mice. BEHAVIOURAL BRAIN RESEARCH 2016; 298:202-209 (SCI).
  13. Liu, Y.-W., Liu, W.-H., Wu, C.-C., Juan, Y.-C., Wu, Y.-C., Tsai, H.-P., Wang, S., Tsai, Y.-C.. Psychotropic effects of Lactobacillus Plantarum PS128 in early life-stressed and naïve adult mice. BRAIN RESEARCH 2016; 1631:1-12 (SCI).
  14. Mosa, AJ; Wang, S; Tan, YF; Wojtowicz, JM. Organotypic Slice Cultures for Studies of Postnatal Neurogenesis. Jove-Journal of Visualized Experiments 2015; 97(dio:10.3791/52353): (OI).
  15. Fang, S.-Y., Wang, S., Huang, N., Yeh, H.-H., Chen, C.-Y.. Prenatal infection and autism spectrum disorders in childhood: A population-based case-control study in Taiwan. PAEDIATRIC AND PERINATAL EPIDEMIOLOGY 2015; 29(4):307-16 (SCI).
  16. Lin, Y.-L. and Wang, S.. Prenatal LPS exposure increases depression-like behaviors and reduces hippocampal neurogenesis in adult rats. BEHAVIOURAL BRAIN RESEARCH 2014; 259:24-34 (SCI).
  17. Lin, Y.-L., Lin, S.-Y., Wang, S.. Prenatal lipopolysaccharide exposure increases anxiety-like behaviors and enhances stress-induced corticosterone responses in adult rats. BRAIN BEHAVIOR AND IMMUNITY 2012; 26(3):459-468 (SCI).
  18. Wu, H.H. and Wang, S.. Strain differences in the chronic mild stress animal model of depression. BEHAVIOURAL BRAIN RESEARCH 2010; 213(1):94-102 (SCI).
  19. Ho, Y.-C. and Wang, S.. Adult neurogenesis is reduced in the dorsal hippocampus of rats displaying learned helplessness behavior. Neurosciences 2010; 171(1):153-61 (SCI).
  20. Wang, S., Yan J.Y., Lo, Y.K., Carvey, P.M. and Ling, Z.. Dopaminergic and serotoninergic deficiencies in young adult rats prenatally exposed to the bacterial lipopolysaccharide. BRAIN RESEARCH 2009; 1265:196-204 (SCI).
  21. Winocur, G., Wojtowicz, J.M., Sekeres, M., Snyder, J.S., Wang, S.. Inhibition of neurogenesis interferes with hippocampus-dependent memory function. Hippocampus 2006; 16(3):296-304 (SCI).
  22. Wang, S., Kee, N., Preston, E. and Wojtowicz, J.M.. Electrophysiological correlates of neural plasticity compensating for ischemia-induced damage in the hippocampus. EXPERIMENTAL BRAIN RESEARCH 2005; 165(2):250-60. (SCI).

受邀演講

  1. 2017/3/26 Animal studies of the potential of psychobiotics in the treatment of major depression 中華民國解剖學學會/第31界生物醫學聯合學術年會
  2. 2013/3/23 The Potential Roles of Adult Neurogenesis and Maternal Infection in the Etiology of Major Depression中華民國解剖學學會/第28屆生物醫學聯合學術年會